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Found 3 Enz. Inhib. hit(s) with Target = 'Protein O-GlcNAcase' and Ligand = 'BDBM50508753'
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50508753(CHEMBL4580690)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant human full length OGA using FM-GlcNAc as substrate preincubated for 60 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50508753(CHEMBL4580690)
Affinity DataIC50:  170nMAssay Description:Inhibition of OGA in HEK293 cells induced with human Tau P30IL mutant assessed as increase in O-GlcNAcylated protein levels measured after 6 hrs by H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50508753(CHEMBL4580690)
Affinity DataIC50:  170nMAssay Description:Inhibition of OGA in HEK293 cells assessed as increase in O-GlcNAcylated protein level by Hoechst staining based microscopic methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed