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Found 7 Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase ROS' and Ligand = 'BDBM158154'
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of ROS1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human TEL (336 residues) fused-ROS1 (1891 to 2347 residues) (unknown origin) expressed in mouse BAF3 cells assessed as cell growth inhi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  7nMAssay Description:Inhibition of ROS1 (unknown origin) in presence of gamma33-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  7nMAssay Description:Inhibition of ROS1 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  7nMAssay Description:Inhibition of ROS1 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  12nMAssay Description:Inhibition of ROS1 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  12nMAssay Description:Inhibition of ROS1 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed