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Found 3 Enz. Inhib. hit(s) with Target = 'Pyruvate kinase PKM' and Ligand = 'BDBM23411'
TargetPyruvate kinase PKM(Homo sapiens (Human))
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM23411(5,6,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...)
Affinity DataIC50:  1.25E+4nMAssay Description:Inhibition of recombinant human N-terminal His6/SUMO-tagged PKM2 expressed in Escherichia coli BL21 using PEP as substrate incubated for 30 mins in p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM23411(5,6,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...)
Affinity DataIC50:  1.25E+4nMAssay Description:Inhibition of PKM2 (unknown origin) Lys207, Hie78, Asp177, Asn75, Thr129, Gly128, Arg73 residuesMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM23411(5,6,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of recombinant human N-terminal His6/SUMO-tagged PKM1 expressed in Escherichia coli BL21 using PEP as substrate incubated for 30 mins in p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed