Found 9 Enz. Inhib. hit(s) with Target = 'RAC-beta serine/threonine-protein kinase' and Ligand = 'BDBM50398379' TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Affinity DataIC50: 1.70nMAssay Description:Envision model plate reader (Molecular Devices)White 384-well plate (Thermo, Art. No. #264706)Main reagents included in an HTRF kinEASE TK kit (Cisbi...More data for this Ligand-Target Pair
3D Structure (crystal)TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Affinity DataIC50: 1.70nMAssay Description:After all the reagents were prepared according to the above method, except for the enzyme, the reagents were equilibrated to the room temperature and...More data for this Ligand-Target Pair
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Affinity DataIC50: 1.70nMAssay Description:a) first, a compound stock solution (10 mM DMSO solution) was diluted with DMSO to obtain a 100 µM compound solution, the compound solution was dilut...More data for this Ligand-Target Pair
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Affinity DataIC50: 3.80nMAssay Description:Inhibition of N-terminal GST-tagged human AKT2 (120 to 481 residues) expressed in baculovirus infected Sf21 cells incubated for 1 hr in presence of A...More data for this Ligand-Target Pair
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Affinity DataIC50: 18nMAssay Description:Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt2 expressed in recombinant baculovirus system using fluo...More data for this Ligand-Target Pair
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Affinity DataIC50: 18nMAssay Description:Inhibition of Akt2 (unknown origin)More data for this Ligand-Target Pair
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Affinity DataIC50: 32nMAssay Description:Inhibition of full length human Akt2 S474D mutant using GRPRTSSFAEGKK as substrate incubated for 40 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Affinity DataIC50: 48nMAssay Description:Inhibition of recombinant AKT2 (120 to 481 end residues) (unknown origin) catalytic domain expressed in Sf21 cells using peptide substrate incubated ...More data for this Ligand-Target Pair
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Nanjing Chia Tai Tianqing Pharmaceutical
US Patent
Affinity DataKd: 35nMAssay Description:Binding affinity to wild-type human partial length AKT2 expressed in bacterial expression system assessed as residual binding level by Kinomescan met...More data for this Ligand-Target Pair
