Found 7 Enz. Inhib. hit(s) with Target = 'RAF proto-oncogene serine/threonine-protein kinase' and Ligand = 'BDBM88120' 
Affinity DataIC50: 0.200nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:C-Raf TR refers to a truncated C-Raf protein, a Δ1-324 deletion mutant.C-Raf FL refers to the full-length C-Raf protein.Full length MEK1 with an...More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of CRAF Y340E/Y341E mutant (unknown origin) using human MEK1 K97R mutant as substrate pretreated for 30 mins followed by substrate additio...More data for this Ligand-Target Pair
Affinity DataIC50: 8.60nMAssay Description:Inhibition of human recombinant cRAF measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.60nMAssay Description:Inhibition of human recombinant cRAF measured after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKd: 3.60nMAssay Description:Binding affinity to wild-type human partial length CRAF (I330 to T640 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
Affinity DataEC50: 14nMAssay Description:Inhibition of CRAF in human Calu6 cells assessed as reduction MEK phosphorylation measured after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
