Found 5 Enz. Inhib. hit(s) with Target = 'Receptor-interacting serine/threonine-protein kinase 1' and Ligand = 'BDBM50233233' TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Denali Therapeutics
US Patent
Denali Therapeutics
US Patent
Affinity DataIC50: 500nMAssay Description:Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Denali Therapeutics
US Patent
Denali Therapeutics
US Patent
Affinity DataIC50: 500nMAssay Description:Assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10.1 μl/well using 10 nM of GS...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Denali Therapeutics
US Patent
Denali Therapeutics
US Patent
Affinity DataIC50: 631nMAssay Description:Displacement of (14-(2-{[3-({2-{[4-(cyanomethyl)phenyl]amino}-6-[(5-cyclopropyl-1H-pyrazol-3-yl)-amino]-4-pyrimidinyl}amino)propyl]amino}-2-oxoethyl)...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Denali Therapeutics
US Patent
Denali Therapeutics
US Patent
Affinity DataIC50: 794nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Denali Therapeutics
US Patent
Denali Therapeutics
US Patent
Affinity DataIC50: <1.00E+3nMAssay Description:Fluorescent polarization binding assay was performed in polystyrene low volume 384-well black plate, at Room Temperature (RT) in a final volume of 10...More data for this Ligand-Target Pair
