Found 19 Enz. Inhib. hit(s) with Target = 'Replicase polyprotein 1ab' and Ligand = 'BDBM420296' 
Affinity DataKi: 30nM IC50: 31nMAssay Description:The assays were carried out with 20 nM enzyme (except for MPI3, for which 10 nM enzyme was used) and 10 μM substrate at 37oC with continuous sha...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 8nMAssay Description:FRET-based enzymatic assay.More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:SARS-CoV-2 3CLpro expression and purification is based on a published procedure and our modified protocol is found in the supplementary file. A highl...More data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:The assays are from references cited in this article.More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibitory activity against cell free dihydrofolate redutase (DHFR) from Mycobacterium lufuMore data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:The assays are from references cited in this article.More data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:Functional Histamine H1 receptor antagonistic activity in vitro assay on guinea pig ileumMore data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:Tested for inhibition against dihydro folate reductase in Pigeon liverMore data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:Recombinant SARS-CoV-2 Mpro was expressed and purified from Escherichia coli (E. coli) (18, 25). A fluorescently labeled substrate, MCA-AVLQ SGFR-Lys...More data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:Inhibition of SARS-CoV-2 3CL proteaseMore data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:Inhibition of SARS-CoV-2 main protease expressed in Escherichia coli using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as substrate preincubated for 10 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 530nMAssay Description:Inhibition of SARS-CoV-2 main protease expressed in Escherichia coli using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as substrate by FRET based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 530nMAssay Description:Inhibition of Severe acute respiratory syndrome coronavirus 2 MPro incubated for 24 hrs by plaque assayMore data for this Ligand-Target Pair
Affinity DataEC50: 530nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
Affinity DataEC50: 420nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Affinity DataEC50: 720nMAssay Description:In vitro inhibition of viral main protease inhibitors against SARS-CoV-2. (A and B) Vero E6 cells were treated with a series concentration of indicat...More data for this Ligand-Target Pair
Affinity DataEC50: 530nMAssay Description:In vitro inhibition of viral main protease inhibitors against SARS-CoV-2. (A and B) Vero E6 cells were treated with a series concentration of indicat...More data for this Ligand-Target Pair
