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Found 4 Enz. Inhib. hit(s) with Target = 'Replicase polyprotein 1ab' and Ligand = 'BDBM423411'
TargetReplicase polyprotein 1ab(2019-nCoV)
Acea Therapeutics

US Patent
LigandPNGBDBM423411(US11753373, Compound A-1-h | WO2005113580-Ex-05 | ...)
Affinity DataIC50:  10.2nMAssay Description:Mpro activity was measured according to the manufacturer's protocol (BPS Biosciences, cat #78042-2) in 384-well plates. The included recombinant un-t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Pfizer

WIPO
LigandPNGBDBM423411(US11753373, Compound A-1-h | WO2005113580-Ex-05 | ...)
Affinity DataIC50:  38nMAssay Description:The SARS 3CLpro FRET assay measures the protease catalyzed cleavage of TAMRA- SITSAVLQSGFRKMK-(DABCYL)-OH to TAMRA - SITSAVLQ and SGFRKMK- (DABCYL)-O...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Pfizer

WIPO
LigandPNGBDBM423411(US11753373, Compound A-1-h | WO2005113580-Ex-05 | ...)
Affinity DataIC50:  38nMAssay Description:Please point to the patents.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Pfizer

WIPO
LigandPNGBDBM423411(US11753373, Compound A-1-h | WO2005113580-Ex-05 | ...)
Affinity DataEC50:  2.00E+4nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed