Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) with Target = 'Replicase polyprotein 1ab' and Ligand = 'BDBM423464'
TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423464(WO2006061714-ID-09 | WO2006061714, P38.7 | cmdc.20...)
Affinity DataEC50:  3.60E+3nMAssay Description:Protection from SARS Infection: Neutral Red Endpoint The ability of compounds to protect cells against infection by the SARS coronavirus is measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423464(WO2006061714-ID-09 | WO2006061714, P38.7 | cmdc.20...)
Affinity DataIC50: 30nMAssay Description:Please point to the patents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
Pfizer

WIPO
LigandPNGBDBM423464(WO2006061714-ID-09 | WO2006061714, P38.7 | cmdc.20...)
Affinity DataIC50: 32nMAssay Description:The SARS 3CLpro FRET assay measures the protease catalyzed cleavage of TAMRA- SITSAVLQSGFRKMK-(DABCYL)-OH to TAMRA - SITSAVLQ and SGFRKMK- (DABCYL)-O...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2020
Entry Details
WIPO WO2005113580

TargetReplicase polyprotein 1ab(SARS coronavirus Urbani)
Pfizer

WIPO
LigandPNGBDBM423464(WO2006061714-ID-09 | WO2006061714, P38.7 | cmdc.20...)
Affinity DataIC50: 3.20E+4nM EC50:  3.60E+6nMAssay Description:Proteolytic activity of Coronavirus 3C protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS 3CI_pro FRET as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details
WIPO WO2006061714