Report error Found 18 Enz. Inhib. hit(s) with Target = 'Replicase polyprotein 1ab' and Ligand = 'BDBM429505'
Affinity DataEC50: 35nMAssay Description:To evaluate the anti-HSV activity of 1, 17 or Brequinar by plaque reduction assays (PRA), Vero cells were seeded in 24-well plates at a density of 70...More data for this Ligand-Target Pair
Affinity DataEC50: 74nMAssay Description:The ability of compounds to protect cells against infection by SARS-CoV-2 is measured by a cell viability assay similar to that described in Weislow,...More data for this Ligand-Target Pair
Affinity DataEC50: 147nMAssay Description:To evaluate the anti-HSV activity of 1, 17 or Brequinar by plaque reduction assays (PRA), Vero cells were seeded in 24-well plates at a density of 70...More data for this Ligand-Target Pair
Affinity DataEC50: 590nMAssay Description:These include a rapid screening replicon assay using baby hamster kidney (BHK) cells with noninfectious SARS-CoV-2, in which the spike protein in the...More data for this Ligand-Target Pair
Affinity DataEC50: 730nMAssay Description:Inhibition of SARS-CoV-2 RdRp transfected in human A549 cells incubated for 24 hrs by CCK-8 assayMore data for this Ligand-Target Pair
Affinity DataEC50: 770nMAssay Description:Vero-E6 cells were seeded at 4 x 10E5 cells/well in 12-well plates and infected for 1 hour with the SARS-CoV-2 isolate USA-WA1/2020 at an MOI of 0.01...More data for this Ligand-Target Pair
Affinity DataEC50: 770nMAssay Description:To evaluate the anti-HSV activity of 1, 17 or Brequinar by plaque reduction assays (PRA), Vero cells were seeded in 24-well plates at a density of 70...More data for this Ligand-Target Pair
Affinity DataEC50: 770nMAssay Description:These assays are from various references.More data for this Ligand-Target Pair
Affinity DataEC50: 770nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Affinity DataEC50: 1.05E+3nMAssay Description:Inhibition of SARS-CoV-2 RdRp transfected in HEK293T cells incubated for 24 hrs by CCK-8 assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.10E+3nMAssay Description:The antiviral activity of compounds was examined by evaluating the cytopathic effect in Vero-E6 cells grown at 37°C in a 5% CO2 atmosphere for 72 h u...More data for this Ligand-Target Pair
Affinity DataIC50: 1.19E+3nMAssay Description:Inhibition of SARS-CoV-2 RdRp transfected in human HEK293T cells cotransfected nsp12More data for this Ligand-Target Pair
Affinity DataIC50: 1.56E+3nMAssay Description:Inhibition of SARS-CoV-2 RdRp transfected in human HEK293T cells cotransfected with Cov-Gluc by Gaussia luciferase reporter gene methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.64E+3nMAssay Description:Inhibition of SARS-CoV-2 RdRP using ATP substrate preincubated with compound for 30 mins followed by substrate addition and measured after 30 mins by...More data for this Ligand-Target Pair
Affinity DataIC50: 3.11E+3nMAssay Description:Inhibition of SARS-CoV-2 RdRp transfected in human HEK293T cells cotransfected nsp12 along with nsp14 and nsp10More data for this Ligand-Target Pair
Affinity DataEC50: 7.86E+3nMAssay Description:SARS-CoV-2 was provided by Korea Centers for Disease Control and Prevention (KCDC) . Vero cells were acquired from the ATCC and maintained in the Dul...More data for this Ligand-Target Pair
Affinity DataIC50: 8.24E+3nMAssay Description:Ten-point DRCs were generated for each drug. Vero cells were seeded at 1.2 × 104 cells per well in DMEM, supplemented with 2% FBS and 1× ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.14E+4nMAssay Description:Ten-point DRCs were generated for each drug. Vero cells were seeded at 1.2 × 104 cells per well in DMEM, supplemented with 2% FBS and 1× ...More data for this Ligand-Target Pair
