Found 25 Enz. Inhib. hit(s) with Target = 'Replicase polyprotein 1ab' and Ligand = 'BDBM496902' 
Affinity DataKi: 3nMAssay Description:Inhibitory activity against Dihydrofolate reductase enzyme purified from Plasmodium berghei.More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 3nMAssay Description:Inhibition of SARS-CoV-2 main protease expressed in Escherichia coli using Dabcyl-KTSAVLQSGFRKME-Edans as substrate incubated for 60 mins by FRET bas...More data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Inhibition of SARS CoV-2 main proteaseMore data for this Ligand-Target Pair
Affinity DataKi: 3.10nMAssay Description:Inhibition of wild type SARS-CoV-2 main protease expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using DABCYL-KTSAVLQ1SGFRKM...More data for this Ligand-Target Pair
Affinity DataKi: 3.10nMAssay Description:Binding affinity to SARS CoV-2 main protease by FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.10nMAssay Description:Inhibition of N-terminal His6-tagged SARS-CoV2 Wuhan-Hu-1 main protease expressed in Escherichia coli using Dabcyl-KTSAVLQSGFRKME-Edans as substrate ...More data for this Ligand-Target Pair
Affinity DataKi: 3.11nMAssay Description:The respective human coronavirus Mpro in assay buffer (20 mM Tris-HCl, pH 7.3, 100 mM NaCl, 1 mM EDTA, 5 mM TCEP) and 0.1% BSA was added to assay-rea...More data for this Ligand-Target Pair
Affinity DataIC50: 0.790nMAssay Description:Inhibition of recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli using Ac-Abu-Tle-Leu-Gln-MCA as fluorogenic substrate preincuba...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:The proteolytic activity of the main protease, 3CLpro, of SARS-CoV-2 was monitored using a continuous fluorescence resonance energy transfer (FRET) a...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat. no. 784900) using an Echo 555 acoustic dispenser, and dimethyl sulfoxide ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.30nMAssay Description:Mpro activity was measured according to the manufacturer's protocol (BPS Biosciences, cat #78042-2) in 384-well plates. The included recombinant un-t...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of wild type SARS-CoV-2 main protease expressed in Escherichia coli BL21 (DE3) using DABCYL-KTSAVLQ1SGFRKM-E(EDANS)-NH2 as substrate prein...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:In vitro inhibition of dihydropteroate synthase from Escherichia coli.More data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of full length SARS-CoV-2 3CLpro expressed in Escherichia coli BL21 (DE3) cells using (DABCYL)KTSAVLQSGFRKM(Glu)(EDANS) peptide as substra...More data for this Ligand-Target Pair
Affinity DataIC50: 54nMAssay Description:Inhibition of SARS-CoV-2 3CL protease using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 fluorogenic peptide as substrate incubated for 30 mins and measured by FRET...More data for this Ligand-Target Pair
Affinity DataIC50: 66nMAssay Description:Inhibition of His/SUMO tagged SARS-CoV2 main protease expressed in Escherichia coli BL21 (DE3) cells using DABCYL-Lys-Thr-Ser-Ala-Val-Leu-Gln-Ser-Gly...More data for this Ligand-Target Pair
Affinity DataIC50: 75nMAssay Description:Inhibition of SARS-CoV-2 main protease using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as fluorescent substrate preincubated for 10 mins followed by substrate ad...More data for this Ligand-Target Pair
Affinity DataIC50: 92nMAssay Description:Inhibition of SARS-CoV-2 main protease using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as substrate preincubated for 30 mins followed by substrate addition and m...More data for this Ligand-Target Pair
Affinity DataIC50: 145nMAssay Description:Inhibition of full length C terminal His-tagged Human coronavirus 229E 3CLpro expressed in Escherichia coli Rosetta (DE3) cells using (DABCYL)KTSAVLQ...More data for this Ligand-Target Pair
Affinity DataEC50: 75nMAssay Description:The ability of compounds to prevent SARS-CoV-2 coronavirus-induced cell death or cytopathic effect can be assessed via cell viability, using an assay...More data for this Ligand-Target Pair
Affinity DataEC50: 3.40E+3nMAssay Description:Inhibition of eGFP fused SARS-CoV2 main protease transfected in HEK293T/17 cells incubated for 72 hrs by fluorescence based flow cytometry analysisMore data for this Ligand-Target Pair
