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Found 3 Enz. Inhib. hit(s) with Target = 'Rho-associated protein kinase 1' and Ligand = 'BDBM14031'
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM14031(5-(1,4-diazepane-1-sulfonyl)-1,2-dihydroisoquinoli...)
Affinity DataKi:  31.6nMAssay Description:Inhibition of ROCK-1More data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM14031(5-(1,4-diazepane-1-sulfonyl)-1,2-dihydroisoquinoli...)
Affinity DataKi:  150nM ΔG°:  -39.6kJ/molepH: 7.6 T: 2°CAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM14031(5-(1,4-diazepane-1-sulfonyl)-1,2-dihydroisoquinoli...)
Affinity DataIC50:  759nMAssay Description:Inhibition of ROCK-1 by Immobilized metal ion affinity-based fluorescence polarization assayMore data for this Ligand-Target Pair