Compile Data Set for Download or QSAR
maximum 50k data
Found 3 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase B-raf' and Ligand = 'BDBM88120'
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM88120(US10245267, Example 1156 | US10709712, Example 115...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of full-length BRAF (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM88120(US10245267, Example 1156 | US10709712, Example 115...)
Affinity DataIC50:  78nMAssay Description:Inhibition of RAF in human A-375 cells assessed as reduction in p-ERK levelsMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM88120(US10245267, Example 1156 | US10709712, Example 115...)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to wild-type human partial length BRAF (S429 to E741 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair