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Found 4 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase Chk1' and Ligand = 'BDBM328996'
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM328996(1137477-07-6 | US11787792, Compound Y-081 | US9663...)
Affinity DataIC50:  2nMAssay Description:CHK1 kinase activity was measured in a microfluidic assay that monitors the separation of a phosphorylated product from its substrate. The assay was ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM328996(1137477-07-6 | US11787792, Compound Y-081 | US9663...)
Affinity DataIC50:  2nMAssay Description:CHK1 kinase activity was measured in a microfluidic assay that monitors the separation of a phosphorylated product from its substrate. The assay was ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM328996(1137477-07-6 | US11787792, Compound Y-081 | US9663...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM328996(1137477-07-6 | US11787792, Compound Y-081 | US9663...)
Affinity DataIC50:  310nMAssay Description:Inhibition of CHK1 in human HT-29 cells assessed as abrogation of etoposide-induced G2 checkpoint arrest by ELISAMore data for this Ligand-Target Pair