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Found 4 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase Sgk1' and Ligand = 'BDBM269003'
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM269003(N-[4-(3-Amino-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-ph...)
Affinity DataIC50:  1.60nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM269003(N-[4-(3-Amino-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-ph...)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM269003(N-[4-(3-Amino-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-ph...)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Sgk1(Mus musculus (Mouse))
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM269003(N-[4-(3-Amino-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-ph...)
Affinity DataIC50:  294nMAssay Description:Inhibition of mouse SGK1 in presence 500 uM presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed