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Found 6 Enz. Inhib. hit(s) with Target = 'Sodium channel protein type 9 subunit alpha' and Ligand = 'BDBM342904'
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM342904(1-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphe...)
Affinity DataIC50:  13.5nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM342904(1-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphe...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells assessed as reduction in peak inward current by ionworks quattro electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM342904(1-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphe...)
Affinity DataIC50:  36nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM342904(1-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphe...)
Affinity DataIC50:  36nMAssay Description:Inhibition of mouse Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM342904(1-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphe...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Rattus norvegicus)
Amgen

Curated by ChEMBL
LigandPNGBDBM342904(1-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphe...)
Affinity DataIC50:  4.00E+3nMAssay Description:Binding affinity towards rat forebrain nicotinic acetylcholine receptor using [3H]EB as radioligandMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed