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Found 5 Enz. Inhib. hit(s) with Target = 'Sphingosine kinase 1' and Ligand = 'BDBM50237420'
TargetSphingosine kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237420(CHEMBL4090361)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of SPHK1 in human MDA1483 cells using C17-sphingosine as substrate assessed as reduction in C17-S1P formation preincubated for 30 mins wit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237420(CHEMBL4090361)
Affinity DataIC50:  2nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in ADP formation using sphingosine as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237420(CHEMBL4090361)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in S1P formation using sphingosine as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237420(CHEMBL4090361)
Affinity DataIC50:  35nMAssay Description:Inhibition of SPHK1 in human whole-blood using C17-sphingosine as substrate assessed as reduction in C17-S1P production preincubated for 30 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50237420(CHEMBL4090361)
Affinity DataIC50:  144nMAssay Description:Inhibition of GFP-tagged SK1 (unknown origin) expressed in HEK293 cells using Sph as substrate measured after 30 mins in presence of [gamma32P]ATP by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed