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Found 4 Enz. Inhib. hit(s) with Target = 'TGF-beta receptor type-1' and Ligand = 'BDBM50132987'
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132987(2-[4-(4-Methoxy-phenyl)-1-methyl-1H-pyrazol-3-yl]-...)
Affinity DataIC50:  44nMAssay Description:In vitro inhibitory activity against human Transforming growth factor beta-1 receptor kinase (TGF-beta RIK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132987(2-[4-(4-Methoxy-phenyl)-1-methyl-1H-pyrazol-3-yl]-...)
Affinity DataIC50:  47nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase production in mink lung cells (p3TP Lux)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132987(2-[4-(4-Methoxy-phenyl)-1-methyl-1H-pyrazol-3-yl]-...)
Affinity DataIC50:  61nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase growth in mouse fibroblasts (NIH 3T3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132987(2-[4-(4-Methoxy-phenyl)-1-methyl-1H-pyrazol-3-yl]-...)
Affinity DataIC50:  5.40E+3nMAssay Description:In vitro inhibitory activity against Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed