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Found 4 Enz. Inhib. hit(s) with Target = 'Thymidylate synthase' and Ligand = 'BDBM18767'
TargetThymidylate synthase(Escherichia coli)
Unimore

LigandPNGBDBM18767(1,8-naphthalein derivative, 14 | 4,4-bis(3-bromo-4...)
Affinity DataKi:  900nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Unimore

LigandPNGBDBM18767(1,8-naphthalein derivative, 14 | 4,4-bis(3-bromo-4...)
Affinity DataKi:  4.70E+3nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
Unimore

LigandPNGBDBM18767(1,8-naphthalein derivative, 14 | 4,4-bis(3-bromo-4...)
Affinity DataKi:  6.80E+3nM ΔG°:  -29.0kJ/molepH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Cryptococcus neoformans)
Unimore

LigandPNGBDBM18767(1,8-naphthalein derivative, 14 | 4,4-bis(3-bromo-4...)
Affinity DataKi:  1.30E+4nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed