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Found 7 Enz. Inhib. hit(s) with Target = 'Toll-like receptor 9' and Ligand = 'BDBM50543465'
TargetToll-like receptor 9(Homo sapiens (Human))
Princ

Curated by ChEMBL
LigandPNGBDBM50543465(CHEMBL4636498)
Affinity DataIC50:  210nMAssay Description:Antagonist activity at TLR9 in human pDC assessed as inhibition of ODN2216-induced IFN-alpha production incubated for 24 hrs measured by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 9(Homo sapiens (Human))
Princ

Curated by ChEMBL
LigandPNGBDBM50543465(CHEMBL4636498)
Affinity DataIC50:  320nMAssay Description:Antagonist activity at TLR9 in human whole blood cells assessed as inhibition of ODN-2216 induced IL-6 production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 9(Mus musculus)
Princ

Curated by ChEMBL
LigandPNGBDBM50543465(CHEMBL4636498)
Affinity DataIC50:  510nMAssay Description:Antagonist activity at TLR9 in mouse whole blood cells assessed as inhibition of ODN-2216 induced IL-6 production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 9(Homo sapiens (Human))
Princ

Curated by ChEMBL
LigandPNGBDBM50543465(CHEMBL4636498)
Affinity DataIC50:  510nMAssay Description:Antagonist activity at TLR9 (unknown origin) in PBMC cells assessed as reduction of IL-6 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 9(Homo sapiens (Human))
Princ

Curated by ChEMBL
LigandPNGBDBM50543465(CHEMBL4636498)
Affinity DataIC50:  700nMAssay Description:Antagonist activity at human TLR9 overexpressed in HEK-Blue cells assessed as inhibition of ODN2006-induced NFkappaB and AP-1 activation preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 9(Homo sapiens (Human))
Princ

Curated by ChEMBL
LigandPNGBDBM50543465(CHEMBL4636498)
Affinity DataIC50: >5.00E+4nMAssay Description:Agonist activity at human TLR9 overexpressed in HEK-Blue cells assessed as NFkappaB expression by reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 9(Mus musculus)
Princ

Curated by ChEMBL
LigandPNGBDBM50543465(CHEMBL4636498)
Affinity DataEC50:  25nMAssay Description:Invivo antagonist activity at TLR9 in po dosed C57BL/6 mouse assessed as reduction of CpG-ODN-1585-induced IL-6 production pretreated for 30 mins fol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed