Found 4 Enz. Inhib. hit(s) with Target = 'Transitional endoplasmic reticulum ATPase' and Ligand = 'BDBM50468110' TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
University of Pittsburgh
US Patent
University of Pittsburgh
US Patent
Affinity DataIC50: 49nMAssay Description:To optimize p97 inhibitors, the C-5 trifluoromethylated trifluoromethylated indole 12 was generated as a promising lead structure. In the ADP-Glo ass...More data for this Ligand-Target Pair
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
University of Pittsburgh
US Patent
University of Pittsburgh
US Patent
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant full length human p97 (1 to 806 residues) expressed in Escherichia coli Rosetta 2 (DE3) using 100 uM ATP as substrate after...More data for this Ligand-Target Pair
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
University of Pittsburgh
US Patent
University of Pittsburgh
US Patent
Affinity DataEC50: 1.90E+4nMAssay Description:Inhibition of human p97 in human HeLa cells harboring UbG76V-GFP assessed as accumulation of UbG76V after 1 hr by microscopic analysisMore data for this Ligand-Target Pair
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
University of Pittsburgh
US Patent
University of Pittsburgh
US Patent
Affinity DataEC50: >4.00E+4nMAssay Description:Inhibition of human p97 in human HeLa cells harboring UbG76V-GFP assessed as accumulation of UbG76V after 6 hrs by microscopic analysisMore data for this Ligand-Target Pair
