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Found 3 Enz. Inhib. hit(s) with Target = 'Tryptophan 2,3-dioxygenase' and Ligand = 'BDBM50514034'
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50514034(CHEMBL4588805)
Affinity DataKi:  340nMAssay Description:Uncompetitive inhibition of recombinant human TDO expressed in Escherichia coli BL21 (DE3) assessed as assessed as inhibition constant using varying ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50514034(CHEMBL4588805)
Affinity DataIC50:  70nMAssay Description:Inhibition of human TDO transfected in HEK293 cells assessed as reduction in kynurenine production using L-tryptophan as substrate incubated for 12 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Fudan University

Curated by ChEMBL
LigandPNGBDBM50514034(CHEMBL4588805)
Affinity DataIC50:  870nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli BL21 (DE3) assessed as reduction in conversion of L-tryptophan to N-formyl kynureni...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed