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Found 3 Enz. Inhib. hit(s) with Target = 'Tryptophan 2,3-dioxygenase' and Ligand = 'BDBM50604731'
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Kunming Institute Of Botany

Curated by ChEMBL
LigandPNGBDBM50604731(CHEMBL5204091)
Affinity DataKi:  730nMAssay Description:Competitive inhibition of recombinant human TDO measured by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Kunming Institute Of Botany

Curated by ChEMBL
LigandPNGBDBM50604731(CHEMBL5204091)
Affinity DataIC50:  160nMAssay Description:Inhibition of recombinant human TDO assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate and measured after 15 minsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Kunming Institute Of Botany

Curated by ChEMBL
LigandPNGBDBM50604731(CHEMBL5204091)
Affinity DataIC50:  1.87E+3nMAssay Description:Inhibition of TDO in human HEK293 cells assessed as reduction in kynurenine formation using L-tryptophan as substrate by absorbance based analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed