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Found 2 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK1/JAK2' and Ligand = 'BDBM159748'
TargetTyrosine-protein kinase JAK1/JAK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM159748(US10966980, Example 2 | US9035074, 2)
Affinity DataIC50:  163nMAssay Description:Inhibition of JAK2/JAK1 in human whole blood assessed as reduction in IFNgamma induced STAT1 phosphorylation preincubated for 45 mins followed by IFN...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1/JAK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM159748(US10966980, Example 2 | US9035074, 2)
Affinity DataIC50:  271nMAssay Description:Inhibition of JAK2/JAK1 in human whole blood assessed as reduction in IL-27 induced STAT3 phosphorylation preincubated for 45 mins followed by IL-27 ...More data for this Ligand-Target Pair