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Found 3 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2 [831-1132]' and Ligand = 'BDBM264221'
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM264221((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...)
Affinity DataIC50:  2.58E+3nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM264221((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...)
Affinity DataIC50:  2.58E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM264221((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...)
Affinity DataIC50:  2.58E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent