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Report error Found 5 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase Tec' and Ligand = 'BDBM209866'
TargetTyrosine-protein kinase Tec(Human)
Pfizer

LigandPNGBDBM209866(PF-06651600 | US9617258, Example 5 | US11111242, E...)
Affinity DataKi:  0.679nMpH: 7.5Assay Description:Assay buffer was 20 mM HEPES, pH 7.5, 10 mM MgCl2, 0.01% BSA, 1 mM DTT, 0.0005% Tween 20, and 2% DMSO. Inactivation kinetic reactions were performed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase Tec(Human)
Pfizer

LigandPNGBDBM209866(PF-06651600 | US9617258, Example 5 | US11111242, E...)
Affinity DataIC50: 155nMAssay Description:Inhibition of TEC (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Tec(Human)
Pfizer

LigandPNGBDBM209866(PF-06651600 | US9617258, Example 5 | US11111242, E...)
Affinity DataIC50: 592nMAssay Description:Inhibition of full length human His-tagged TEC in presence of 1 mM ATP by KT178 probe based TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Tec(Human)
Pfizer

LigandPNGBDBM209866(PF-06651600 | US9617258, Example 5 | US11111242, E...)
Affinity DataIC50: 592nMpH: 7.4 T: 2°CAssay Description:Test compounds were solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. Compounds were diluted in DMSO to create an 11-point ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase Tec(Human)
Pfizer

LigandPNGBDBM209866(PF-06651600 | US9617258, Example 5 | US11111242, E...)
Affinity DataKi:  679nMAssay Description:Inhibition of full length human His-tagged TEC by KT178 probe based TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2020
Entry Details Article
PubMed