Found 50 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein phosphatase non-receptor type 1' and Ligand = 'BDBM50346601' TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataKi: 6.00E+3nMAssay Description:Mixed type inhibition of human recombinant PTP-1B expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataKi: 6.00E+3nMAssay Description:Mixed-type inhibition of purified human GST-tagged PTP-1B using p-nitrophenylphosphate as substrate by double-reciprocal plot methodMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of human recombinant PTP1B using pNPP as substrate assessed as reduction in p-nitrophenol release incubated for 30 mins by absorbance base...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of PTP1B (unknown origin) pre-incubated for 10 mins before addition of p-nitrophenyl phosphate substrate and measured 30 mins post substra...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 730nMAssay Description:Inhibition of recombinant human PTP1B using pNPP as substrate incubated for 10 mins prior to substrate addition measured after 30 mins by microplate ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 990nMAssay Description:Inhibition of PTP1B (unknown origin) by DAS-ELISAMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant PTP1B using pNPP as substrate assessed as rate of hydrolysis incubated for 10 mins prior to substrate addition measur...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of recombinant human PTP1B (1 to 322 residues) expressed in Escherichia coli using pNPP as substrate preincubated for 10 mins followed by ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of recombinant PTP1B (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of recombinant PTP1B (unknown origin) assessed as pNPP hydrolysis after 30 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of recombinant PTP1B (unknown origin) using pNPP as substrate incubated for 30 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 1.62E+3nMAssay Description:Inhibition of PTP1B (unknown origin) using pNPP as substrateMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 1.86E+3nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 1.90E+3nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 1.95E+3nMpH: 6.5Assay Description:Briefly, the tested compounds were solubilized in DMSO and serially diluted into concentrations for the inhibitory test. The assays were carried out ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PTP1B (unknown origin) using p-nitrophenyl phosphate as substrate measured after 30 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 2.01E+3nMAssay Description:Inhibition of GST-tagged PTP1B (unknown origin) using pNPP as substrate measured for 2 mins by colorimetric analysisMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 2.06E+3nMAssay Description:Inhibition of recombinant human PTP1B using pNNP as substrate after 30 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of PTP1B (unknown origin) using pNPP as substrate after 3 mins by colorimetric analysisMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of recombinant PTP1B catalytic domain (unknown origin) assessed as reduction in pNP formation using pNPP as substrate by absorbance based ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of recombinant human PTP1B catalytic domain (91 to 1053 residues) expressed in Escherichia coli BL21-codon plus (DE3) using pNPP as substr...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 2.56E+3nMAssay Description:Inhibition of PTP1B (unknown origin) using pNPP substrate measured after 3 mins by colorimetric assayMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of GST-tagged PTP1B (unknown origin) using pNPP as substrate measured for 3 mins by colorimetric assayMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human PTP1BMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of GST-tagged PTP1B (unknown origin) using pNPP as substrate measured for 3 mins by colorimetric assayMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 2.69E+3nMAssay Description:Inhibition of human recombinant GST-tagged PTP1B expressed in Escherichia coli BL21 (DE3) using pNPP as substrate measured for 2 mins by colorimetric...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 2.95E+3nMAssay Description:Inhibition of PTP1B (unknown origin) by SpectraMax 340 microplate reader AnalysisMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 2.96E+3nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as reduction in nitrophenol production using pNPP as substrate incubated for 30 mins by EnVisionMultila...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 3.02E+3nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 3.02E+3nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 3.02E+3nMAssay Description:Inhibition of recombinant human PTP1B catalytic domain assessed as hydrolysis of pNPP after 2 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human PTP1BMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 3.32E+3nMAssay Description:Compound is evaluated for the inhibition of porcine plasma Angiotensin I converting enzymeMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 3.48E+3nMAssay Description:Inhibition of recombinant human PTP1B catalytic domain expressed in Escherichia coli BL21-CodonPlus (DE3) using pNPP as substrate measured for 2 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 3.84E+3nMAssay Description:Inhibition of GST-tagged human recombinant PTP1B assessed as dephosphorylation of para-nitrophenyl phosphate after 10 mins by spectrophotometric anal...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of N-terminal GST tagged recombinant human PTP1B catalytic domain (1 to 321 residues) expressed in Escherichia coli using pNPP as substrat...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of N-terminal GST tagged recombinant human PTP1B catalytic domain (1 to 321 residues) expressed in Escherichia coli using pNPP as substrat...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 5.05E+3nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 5.05E+3nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of GST-tagged human recombinant PTP1B using para-nitrophenyl phosphate as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of human recombinant PTP1B after 30 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of human recombinant PTP-1B expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate after 1 hrMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of purified human GST-tagged PTP-1B using p-nitrophenylphosphate as substrate by spectrophotometryMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 4.07E+4nMAssay Description:Inhibition of PTP1B (unknown origin) using pNPP as substrate incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 4.07E+4nMAssay Description:Inhibition of PTP1B (unknown origin) using pNPP as substrate incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Universidad Aut£Noma Del Estado De Morelos
Curated by ChEMBL
Affinity DataIC50: 2.39E+6nMAssay Description:Inhibition of human recombinant GST-tagged PTP1B catalytic domain expressed in Escherichia coli BL21-Conden plus (DE3) using pNPP as substrateMore data for this Ligand-Target Pair
