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Found 7 Enz. Inhib. hit(s) with Target = 'Tyrosyl-DNA phosphodiesterase 2' and Ligand = 'BDBM50438865'
TargetTyrosyl-DNA phosphodiesterase 2(Homo sapiens (Human))
National Institutes of Health

LigandPNGBDBM50438865(2,4-Dioxo-10-phenyl-pyrimido[4,5-b]quinoline-8-car...)
Affinity DataIC50:  180nMpH: 7.5Assay Description:Ten-million cells (1 x 107), either human, chicken DT40 wild type, or knockout for TDP2 and complemented with human TDP2, were collected, washed, and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 2(Homo sapiens (Human))
National Institutes of Health

LigandPNGBDBM50438865(2,4-Dioxo-10-phenyl-pyrimido[4,5-b]quinoline-8-car...)
Affinity DataIC50:  300nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 2(Homo sapiens (Human))
National Institutes of Health

LigandPNGBDBM50438865(2,4-Dioxo-10-phenyl-pyrimido[4,5-b]quinoline-8-car...)
Affinity DataIC50:  640nMAssay Description:Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 2(Homo sapiens (Human))
National Institutes of Health

LigandPNGBDBM50438865(2,4-Dioxo-10-phenyl-pyrimido[4,5-b]quinoline-8-car...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of N-terminal His-tagged human TDP2 expressed in Escherichia coli BL21 using 4-nitrophenyl phenylphosphonate as substrate incubated for 60...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Homo sapiens (Human))
National Institutes of Health

LigandPNGBDBM50438865(2,4-Dioxo-10-phenyl-pyrimido[4,5-b]quinoline-8-car...)
Affinity DataIC50:  3.71E+3nMAssay Description:Inhibition of TDP2 (unknown origin) using 5'-Y-TCCGTTGAAGCCTGCTTT-3' as substrate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 2(Mus musculus (Mouse))
National Institutes of Health

LigandPNGBDBM50438865(2,4-Dioxo-10-phenyl-pyrimido[4,5-b]quinoline-8-car...)
Affinity DataIC50: >1.11E+5nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 2(Homo sapiens (Human))
National Institutes of Health

LigandPNGBDBM50438865(2,4-Dioxo-10-phenyl-pyrimido[4,5-b]quinoline-8-car...)
Affinity DataEC50:  500nMAssay Description:Inhibition of TDP2 (unknown origin) using 4-nitrophenyl phenylphosphonate as substrate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed