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Found 6 Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM290889'
LigandPNGBDBM290889(1-[2-fluoro-4- (tetrahydro-2H- pyran-4-yl)phenyl]-...)
Affinity DataIC50:  0.770nMAssay Description:Inhibition of PDE10A (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM290889(1-[2-fluoro-4- (tetrahydro-2H- pyran-4-yl)phenyl]-...)
Affinity DataIC50:  0.770nMAssay Description:Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM290889(1-[2-fluoro-4- (tetrahydro-2H- pyran-4-yl)phenyl]-...)
Affinity DataIC50: <1nMpH: 7.4 T: 2°CAssay Description:Human PDE1A, 3A, 4D2, 5A1, 7B, 8A1, 9A2, and 11A4 enzymes were purchased from BPS Bioscience. Human PDE6AB enzyme was purchased from Scottish Biomedi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM290889(1-[2-fluoro-4- (tetrahydro-2H- pyran-4-yl)phenyl]-...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of PDE10A2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM290889(1-[2-fluoro-4- (tetrahydro-2H- pyran-4-yl)phenyl]-...)
Affinity DataKd:  4.70nMAssay Description:Binding affinity to PDE10A in rat brain nucleus accumbens by saturation binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM290889(1-[2-fluoro-4- (tetrahydro-2H- pyran-4-yl)phenyl]-...)
Affinity DataKd:  12nMAssay Description:Binding affinity to PDE10A in rat brain caudate-putamen by saturation binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed