Found 20 Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D' and Ligand = 'BDBM50346088' TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataKi: 38nMAssay Description:Inhibition of rolipram binding to PDE4More data for this Ligand-Target Pair
3D Structure (crystal)TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataKi: 38nMAssay Description:Inhibition of rolipram binding to Phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of PDE4 from U937 monocytic cellsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of phosphodiesterase type 4 isozyme (PDE4) from the U937 human cell line.More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of [3H]rolipram binding in human peripheral blood mononuclear cellsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 73nMAssay Description:Inhibition of human Phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 73nMAssay Description:Affinity for alpha4-beta1 integrin from HL60 cell lysateMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 95nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 95nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 95nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibitory activity against phosphodiesterase 4 carried out in the cytosol of human neutrophilsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibitory concentration against phosphodiesterase 4 (PDE4) in cytosol of human neutrophilsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of PDE4 in the cytosol of human neutrophilsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of phosphodiesterase 4 (PDE4) in human neutrophilsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:inhibition of cAMP-specific phosphodiesterase 4 (PDE4) was determined in cytosol from human neutrophilsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of human phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibitory activity on human eosinophil phosphodiesterase 4.More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 360nMAssay Description:Tested for its ability to inhibit the hydrolysis of cAMP by human monocyte cytosol phosphodiesteraseMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Zambon Group
Curated by ChEMBL
Zambon Group
Curated by ChEMBL
Affinity DataIC50: 3.41E+3nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
