Found 6 Enz. Inhib. hit(s) with Target = 'von Hippel-Lindau disease tumor suppressor' and Ligand = 'BDBM50446138' Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of 6xHis-tagged VHL (unknown origin) expressed in Escherichia coli BL21 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
3D Structure (crystal)Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 4.10E+3nMAssay Description:Binding affinity to VHL E3 ligase (unknown origin) by fluorescence polarization (FP) assayMore data for this Ligand-Target Pair
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of VHL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataKd: 5.40E+3nMAssay Description:Binding affinity to VHL E3 ligase (unknown origin) assessed as dissociation constant by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataKd: 5.50E+3nMAssay Description:Displacement of 19-mer HIF-1alpha peptide from VHL (unknown origin) by isothermal titration calorimetry analysisMore data for this Ligand-Target Pair
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataKd: 5.30E+3nMAssay Description:Binding affinity to N-terminal His6-tagged pVHL (54 to 213 amino acids) (unknown origin) expressed in Escherichia coli BL21 (DE3) by isothermal titra...More data for this Ligand-Target Pair
