Affinity DataKi: 0.0800nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
Affinity DataKi: 0.0880nMAssay Description:The inhibition constant (Ki) is the dissociation constant of an enzyme-inhibitor complex or a protein/small molecule complex, wherein the small molec...More data for this Ligand-Target Pair
Affinity DataKi: <0.5nM IC50: <60nM EC50: 30nMAssay Description:The binding affinities (Ki) of compounds were determined using fluorescence polarization assays (FPA) that measure their ability to competitively dis...More data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
University Of California San Francisco
Curated by ChEMBL
University Of California San Francisco
Curated by ChEMBL
Affinity DataKi: 0.600nMAssay Description:Binding affinity to Bcl-XL assessed as inhibition of Bcl-XL-BAD derived peptide interactionMore data for this Ligand-Target Pair
Affinity DataKi: <1nMAssay Description:Displacement of fluorescein-labeled BAK from His-tagged BCL-XL (unknown origin) after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: <1nM EC50: 8nMAssay Description:The binding affinities (Ki) of compounds were determined using fluorescence polarization assays (FPA) that measure their ability to competitively dis...More data for this Ligand-Target Pair
Affinity DataKi: <1nMAssay Description:Inhibition of Bcl2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: <1nMAssay Description:Inhibition of Bcl-xL (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: <1nMAssay Description:Inhibition of Bcl-w (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: <1nMAssay Description:Inhibition of Bcl-xL (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: <1nMAssay Description:Inhibition of Bcl-2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Binding affinity to Bcl-2 (unknown origin) fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Inhibition of 5-FAM-Bid peptide binding to Bcl-2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Inhibition of 5-FAM-Bid peptide binding to Bcl-XL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: >1nMAssay Description:Binding affinity to bovine beta-casein A1More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Institut De Chimie Des Substances Naturelles
Curated by ChEMBL
Institut De Chimie Des Substances Naturelles
Curated by ChEMBL
Affinity DataKi: >1nMAssay Description:Binding affinity to induced myeloid leukemia cell differentiation protein 1 (unknown origin)More data for this Ligand-Target Pair
TargetBcl-2-like protein 10 [11-204](Homo sapiens (Human))
Institut De Chimie Des Substances Naturelles
Curated by ChEMBL
Institut De Chimie Des Substances Naturelles
Curated by ChEMBL
Affinity DataKi: >1nMAssay Description:Binding affinity to Bcl-b (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Displacement of BODIPY-Bak conjugated peptide from GST-tagged human Wild type Bcl-2-like protein 1 expressed in Escherichia coli BL21 cells at 10 uM ...More data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Binding affinity to Bcl-xlMore data for this Ligand-Target Pair
Affinity DataKi: <40nMAssay Description:Inhibition of BCL-xL (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Affinity DataKi: <40nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
Affinity DataKi: <40nMAssay Description:The fluorescence polarization assays were performed in 96 well polypropylene F-bottom black microplates (Greiner Bio-One) with a final volume of 100 ...More data for this Ligand-Target Pair
TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)(Homo sapiens (Human))
University of Maryland, Baltimore
US Patent
University of Maryland, Baltimore
US Patent
Affinity DataKi: <40nMAssay Description:The fluorescence polarization assays were performed in 96 well polypropylene F-bottom black microplates (Greiner Bio-One) with a final volume of 100 ...More data for this Ligand-Target Pair
Affinity DataKi: 188nMAssay Description:Inhibition of recombinant His6-tagged Bcl-XL expressed in Escherichia coli BL21 (DE3) and Flu-Bak peptide interaction by fluorescence polarization as...More data for this Ligand-Target Pair
Affinity DataKi: 283nMAssay Description:Inhibition of Bcl2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 284nMAssay Description:Inhibition of Bcl-xL (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 285nMAssay Description:Inhibition of Bcl-w (unknown origin)More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Institut De Chimie Des Substances Naturelles
Curated by ChEMBL
Institut De Chimie Des Substances Naturelles
Curated by ChEMBL
Affinity DataKi: >2.00E+4nMAssay Description:Inhibition of 5-FAM-Bid peptide binding to MCL-1 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Institut De Chimie Des Substances Naturelles
Curated by ChEMBL
Institut De Chimie Des Substances Naturelles
Curated by ChEMBL
Affinity DataKi: >2.00E+4nMAssay Description:Binding affinity to Mcl-1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: >2.00E+4nMAssay Description:Binding affinity to Bcl2A1 (unknown origin)More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Institut De Chimie Des Substances Naturelles
Curated by ChEMBL
Institut De Chimie Des Substances Naturelles
Curated by ChEMBL
Affinity DataKi: >2.00E+4nMAssay Description:Binding affinity to Mcl-1More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Institut De Chimie Des Substances Naturelles
Curated by ChEMBL
Institut De Chimie Des Substances Naturelles
Curated by ChEMBL
Affinity DataKi: 2.08E+4nMAssay Description:Displacement of fluorescein-labeled BID from His-tagged MCL-1 (unknown origin) after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Institut De Chimie Des Substances Naturelles
Curated by ChEMBL
Institut De Chimie Des Substances Naturelles
Curated by ChEMBL
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity to Mcl-1 by competitive fluorescence polarization assayMore data for this Ligand-Target Pair