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Isocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Agios Pharmaceuticals

Curated by ChEMBL

BDBM279989(US10028961, Compound 142 | US10172864, Compound 14...)

IC50: 0.25nMAssay Description:Inhibition of IDH1 R132H mutant in glioma patient-derived human TS603 neurosphere cells assessed as reduction in 2-HG content using alpha-ketoglutara...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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Details Article PubMed

Filter my 34 hits

Targets 20▿
- Platelet-derived growth factor receptor beta 3
- Cyclin-dependent kinase 2 2
- Tyrosine-protein kinase Lck 2
- Cyclin-dependent kinase 1 2
- Tyrosine-protein kinase ABL1 2
- Proto-oncogene tyrosine-protein kinase Src 2
- Tyrosine-protein kinase Fyn 2
- Cyclin-dependent kinase 7 2
- Fibroblast growth factor receptor 1 2
- Receptor tyrosine-protein kinase erbB-2 2
- Cyclin-dependent kinase 4 2
- Epidermal growth factor receptor 2
- Platelet-derived growth factor receptor alpha 2
- Mitogen-activated protein kinase 1 1
- Casein kinase I isoform alpha/delta/epsilon/gamma-1/gamma-2 1
- cAMP-dependent protein kinase catalytic subunit alpha/beta/gamma 1
- Glycogen synthase kinase-3 1
- Vascular endothelial growth factor receptor 1/2/3 1
- Insulin receptor 1
- Focal adhesion kinase 1 1
Publications 2▿
- J Med Chem 48: 8163-73 (2005) 21
- Proc Natl Acad Sci U S A 104: 20523-8 (2007) 13
Institutions 2▿
- Johnson & Johnson Pharmaceutical Research And Development 21
- University Of Oxford 13
Affinity: 3 to 1.0E+5 nM▿
- IC50 34
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1