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TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM19461(5,7-dihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2H-1...)
Affinity DataKi:  0.00110nM IC50: 1.00E+3nMAssay Description:Inhibition assay using aromatase enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM92556(Neoflavonoid, 8)
Affinity DataKi:  0.00182nM IC50: 1.21E+4nMAssay Description:Inhibition assay using aromatase enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM92555(Neoflavonoid, 7)
Affinity DataKi:  0.00216nMAssay Description:Inhibition assay using aromatase enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM92557(Neoflavonoid, 9)
Affinity DataKi:  0.00256nMAssay Description:Inhibition assay using aromatase enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM92559(Neoflavonoid, 11)
Affinity DataKi:  0.00425nMAssay Description:Inhibition assay using aromatase enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM92560(Neoflavonoid, 19)
Affinity DataKi:  0.00597nMAssay Description:Inhibition assay using aromatase enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM92558(Neoflavonoid, 10)
Affinity DataKi:  0.00838nMAssay Description:Inhibition assay using aromatase enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM92561(Neoflavonoid, 20)
Affinity DataKi:  0.0118nMAssay Description:Inhibition assay using aromatase enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM13061(CHEMBL1444 | 4-[(4-cyanophenyl)(1H-1,2,4-triazol-1...)
Affinity DataKi:  0.0200nMAssay Description:Competitive inhibition of human aromatase using dibenzylfluorescein substrate after 10 mins preincubation measured every 10 sec for 5 mins by Michael...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataKi:  0.0500nMAssay Description:Competitive inhibition of human aromatase using dibenzylfluorescein substrate after 10 mins preincubation measured every 10 sec for 5 mins by Michael...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50366125(CHEMBL1957214)
Affinity DataKi:  0.0600nMAssay Description:Competitive inhibition of human aromatase using dibenzylfluorescein substrate after 10 mins preincubation measured every 10 sec for 5 mins by Michael...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM10015(NSC719344 | arimidex | 2-[3-(1-cyano-1-methylethyl...)
Affinity DataKi:  0.130nMAssay Description:Competitive inhibition of human aromatase using dibenzylfluorescein substrate after 10 mins preincubation measured every 10 sec for 5 mins by Michael...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50240798(CHEMBL132530 | 4-hyroxyandrostenedione | (8R,9S,10...)
Affinity DataKi:  0.160nMAssay Description:Binding affinity to aromatase (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataKi:  0.600nMAssay Description:Inhibition constant for human aromatase cytochrome P450 19A1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50366128(CHEMBL1957217)
Affinity DataKi:  0.650nMAssay Description:Competitive inhibition of human aromatase using dibenzylfluorescein substrate after 10 mins preincubation measured every 10 sec for 5 mins by Michael...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50398447(Aromasin | EXEMESTANE)
Affinity DataKi:  0.950nMAssay Description:Binding affinity to aromatase (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50011771(CHEMBL281433 | 13-Methyl-10-thiiranyl-1,6,7,8,9,10...)
Affinity DataKi:  1nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM10044((2S,15S)-15-methyl-2-[(methylsulfanyl)methyl]tetra...)
Affinity DataKi:  1nMAssay Description:Aromatase inhibitor potency as iron-binding-related type II difference spectrumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50011771(CHEMBL281433 | 13-Methyl-10-thiiranyl-1,6,7,8,9,10...)
Affinity DataKi:  1nMAssay Description:Inhibition of human placental Cytochrome P450 19A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50014307(CHEMBL98998 | 10-Difluoromethyl-13-methyl-1,6,7,8,...)
Affinity DataKi:  1nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50136071(CHEMBL3753593)
Affinity DataKi:  1nMAssay Description:Inhibition of aromatase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2017
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM10044((2S,15S)-15-methyl-2-[(methylsulfanyl)methyl]tetra...)
Affinity DataKi:  1nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50014316(CHEMBL98537 | 7-(4-Azido-phenylsulfanyl)-10,13-dim...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50014316(CHEMBL98537 | 7-(4-Azido-phenylsulfanyl)-10,13-dim...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50041376((R)-6-Ethyl-10,13-dimethyl-1,6,7,8,9,10,11,12,13,1...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity for human placental microsome Cytochrome P450 19A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50135998(CHEMBL3752668)
Affinity DataKi:  1.40nMAssay Description:Competitive inhibition of human aromatase extracted from placental microsomes after 10 mins in presence of [1beta-3H]androstenedioneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2017
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50135997(CHEMBL3754471)
Affinity DataKi:  1.40nMAssay Description:Competitive inhibition of human aromatase extracted from placental microsomes after 10 mins in presence of [1beta-3H]androstenedioneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2017
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50136000(CHEMBL3754220)
Affinity DataKi:  1.40nMAssay Description:Competitive inhibition of human aromatase extracted from placental microsomes after 10 mins in presence of [1beta-3H]androstenedioneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2017
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50136063(CHEMBL3752102)
Affinity DataKi:  1.40nMAssay Description:Competitive inhibition of human aromatase extracted from placental microsomes after 10 mins in presence of [1beta-3H]androstenedioneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2017
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50136057(CHEMBL3752661)
Affinity DataKi:  1.40nMAssay Description:Competitive inhibition of human aromatase extracted from placental microsomes after 10 mins in presence of [1beta-3H]androstenedioneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2017
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataKi:  1.5nMAssay Description:Aromatase inhibitor potency as iron-binding-related type II difference spectrumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50405683(CHEMBL174909)
Affinity DataKi:  1.5nMAssay Description:Apparent inhibition constant (Ki) for cytochrome P450 19A1 with androstenedioneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM8611(CHEMBL468419 | 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridi...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of aromatase in human placental microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50254017(6-((4-fluorophenyl)(1H-imidazol-1-yl)methyl)benzo[...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of human aromatase-mediated conversion of [1beta3H]androstenedione to estrone by Lineweaver-Burke plot in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM13061(CHEMBL1444 | 4-[(4-cyanophenyl)(1H-1,2,4-triazol-1...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of human aromatase-mediated conversion of [1beta3H]androstenedione to estrone by Lineweaver-Burke plot in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50014299(CHEMBL421018 | 2,2,10,13-Tetramethyl-1,6,7,8,9,10,...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50135970(CHEMBL3752341)
Affinity DataKi:  2.5nMAssay Description:Competitive inhibition of human aromatase extracted from placental microsomes after 5 mins by Dixon plot analysis in presence of [1beta-3H]ADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2017
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50135969(CHEMBL3752315)
Affinity DataKi:  2.5nMAssay Description:Competitive inhibition of human aromatase extracted from placental microsomes after 5 mins by Dixon plot analysis in presence of [1beta-3H]ADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2017
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50421878(CHEMBL2311178)
Affinity DataKi:  2.5nMAssay Description:Competitive inhibition of human aromatase extracted from placental microsomes after 5 mins by Dixon plot analysis in presence of [1beta-3H]ADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2017
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50135916(CHEMBL3752165)
Affinity DataKi:  2.5nMAssay Description:Competitive inhibition of human aromatase extracted from placental microsomes after 5 mins by Dixon plot analysis in presence of [1beta-3H]ADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2017
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50135918(CHEMBL3753803)
Affinity DataKi:  2.5nMAssay Description:Competitive inhibition of human aromatase extracted from placental microsomes after 5 mins by Dixon plot analysis in presence of [1beta-3H]ADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2017
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50135917(CHEMBL3754546)
Affinity DataKi:  2.5nMAssay Description:Competitive inhibition of human aromatase extracted from placental microsomes after 5 mins by Dixon plot analysis in presence of [1beta-3H]ADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2017
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50135922(CHEMBL3752619)
Affinity DataKi:  2.5nMAssay Description:Competitive inhibition of human aromatase extracted from placental microsomes after 5 mins by Dixon plot analysis in presence of [1beta-3H]ADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2017
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50135921(CHEMBL3752011)
Affinity DataKi:  2.5nMAssay Description:Competitive inhibition of human aromatase extracted from placental microsomes after 5 mins by Dixon plot analysis in presence of [1beta-3H]ADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2017
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50135799(CHEMBL3752650)
Affinity DataKi:  2.80nMAssay Description:Competitive inhibition of human aromatase extracted from placental microsomes after 5 mins by Dixon plot analysis in presence of [1beta-3H]ADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2017
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50135858(CHEMBL3754366)
Affinity DataKi:  2.80nMAssay Description:Competitive inhibition of human aromatase extracted from placental microsomes after 5 mins by Dixon plot analysis in presence of [1beta-3H]ADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2017
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50135857(CHEMBL3754285)
Affinity DataKi:  2.80nMAssay Description:Competitive inhibition of human aromatase extracted from placental microsomes after 5 mins by Dixon plot analysis in presence of [1beta-3H]ADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2017
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM50014310(CHEMBL98685 | 13-Methyl-10-vinyl-1,6,7,8,9,10,11,1...)
Affinity DataKi:  3nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetAromatase(Human)
Central Institute of Medicinal and Aromatic Plants

LigandPNGBDBM9955((8S)-2,8,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{1...)
Affinity DataKi:  3.10nM ΔG°:  -12.1kcal/mole IC50: 37nMpH: 7.5 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2006
Entry Details Article
PubMed
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