Affinity DataIC50: 20nMpH: 8.1 T: 2°CAssay Description:RNA-dependent DNA polymerase (RDDP) activity was measured as described[J. Microbiol. 2015, 53:288-293] in Tris·HCl buffer (25 mL, 60 mm, pH 8.1) con...More data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 170nMAssay Description:A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...More data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...More data for this Ligand-Target Pair
Affinity DataIC50: 350nM Kd: 500nMAssay Description:In vitro capsid assembly assay (CAA) was used in a HTS to identify potential inhibitors of capsid assembly. More data for this Ligand-Target Pair
Affinity DataIC50: 370nMT: 2°CAssay Description:A reverse transcriptase (RT) assay kit produced by Roche was selected
for the RT inhibition assay. All the reagents for performing the RT
reaction ...More data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...More data for this Ligand-Target Pair
Affinity DataIC50: 670nMAssay Description:In vitro capsid assembly assay (CAA) was used in a HTS to identify potential inhibitors of capsid assembly. More data for this Ligand-Target Pair
Affinity DataIC50: 690nMT: 2°CAssay Description:A reverse transcriptase (RT) assay kit produced by Roche was selected
for the RT inhibition assay. All the reagents for performing the RT
reaction ...More data for this Ligand-Target Pair
Affinity DataIC50: 890nMAssay Description:In vitro capsid assembly assay (CAA) was used in a HTS to identify potential inhibitors of capsid assembly. More data for this Ligand-Target Pair
Affinity DataIC50: 910nMAssay Description:A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:In vitro capsid assembly assay (CAA) was used in a HTS to identify potential inhibitors of capsid assembly. More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nM Kd: 4.30E+3nMAssay Description:In vitro capsid assembly assay (CAA) was used in a HTS to identify potential inhibitors of capsid assembly. More data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nM Kd: 8.00E+3nMAssay Description:In vitro capsid assembly assay (CAA) was used in a HTS to identify potential inhibitors of capsid assembly. More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMT: 2°CAssay Description:A reverse transcriptase (RT) assay kit produced by Roche was selected
for the RT inhibition assay. All the reagents for performing the RT
reaction ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.10E+3nM Kd: 4.30E+4nMAssay Description:In vitro capsid assembly assay (CAA) was used in a HTS to identify potential inhibitors of capsid assembly. More data for this Ligand-Target Pair
Affinity DataIC50: 7.50E+3nMpH: 7.8 T: 2°CAssay Description:HIV RT-associated RNase H activity was measured as previously
described.[J. Med. Chem. 2014, 57:3223-3234] Briefly, the reaction
mixture comprised ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMpH: 7.8 T: 2°CAssay Description:HIV RT-associated RNase H activity was measured as previously
described.[J. Med. Chem. 2014, 57:3223-3234] Briefly, the reaction
mixture comprised ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.85E+4nMpH: 8.1 T: 2°CAssay Description:RNA-dependent DNA polymerase (RDDP) activity was measured as described[J. Microbiol. 2015, 53:288-293] in Tris·HCl buffer (25 mL, 60 mm, pH 8.1) con...More data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+4nMpH: 7.8 T: 2°CAssay Description:HIV RT-associated RNase H activity was measured as previously
described.[J. Med. Chem. 2014, 57:3223-3234] Briefly, the reaction
mixture comprised ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.90E+4nMpH: 8.1 T: 2°CAssay Description:RNA-dependent DNA polymerase (RDDP) activity was measured as described[J. Microbiol. 2015, 53:288-293] in Tris·HCl buffer (25 mL, 60 mm, pH 8.1) con...More data for this Ligand-Target Pair
Affinity DataIC50: 9.70E+4nMpH: 7.8 T: 2°CAssay Description:HIV RT-associated RNase H activity was measured as previously
described.[J. Med. Chem. 2014, 57:3223-3234] Briefly, the reaction
mixture comprised ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 8.1 T: 2°CAssay Description:RNA-dependent DNA polymerase (RDDP) activity was measured as described[J. Microbiol. 2015, 53:288-293] in Tris·HCl buffer (25 mL, 60 mm, pH 8.1) con...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 7.8 T: 2°CAssay Description:HIV RT-associated RNase H activity was measured as previously
described.[J. Med. Chem. 2014, 57:3223-3234] Briefly, the reaction
mixture comprised ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMpH: 7.8 T: 2°CAssay Description:HIV RT-associated RNase H activity was measured as previously
described.[J. Med. Chem. 2014, 57:3223-3234] Briefly, the reaction
mixture comprised ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 8.1 T: 2°CAssay Description:RNA-dependent DNA polymerase (RDDP) activity was measured as described[J. Microbiol. 2015, 53:288-293] in Tris·HCl buffer (25 mL, 60 mm, pH 8.1) con...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMpH: 8.1 T: 2°CAssay Description:RNA-dependent DNA polymerase (RDDP) activity was measured as described[J. Microbiol. 2015, 53:288-293] in Tris·HCl buffer (25 mL, 60 mm, pH 8.1) con...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 7.8 T: 2°CAssay Description:HIV RT-associated RNase H activity was measured as previously
described.[J. Med. Chem. 2014, 57:3223-3234] Briefly, the reaction
mixture comprised ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 8.1 T: 2°CAssay Description:RNA-dependent DNA polymerase (RDDP) activity was measured as described[J. Microbiol. 2015, 53:288-293] in Tris·HCl buffer (25 mL, 60 mm, pH 8.1) con...More data for this Ligand-Target Pair
