Compile Data Set for Download or QSAR
Report error Found 13 of ki for UniProtKB: P14061
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17289BDBM17289(folliculin | (1S,10R,11S,15S)-5-hydroxy-15-methylt...)
Affinity DataKi:  3nMAssay Description:Inhibition of 17beta-HSD1 assessed as conversion of [14C]estradiol to [14C]estrone using NADP+More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50179201BDBM50179201(5'-O-{9-[3',17'beta-dihydroxy-1',3',5'(10')-estrat...)
Affinity DataKi:  3nMAssay Description:Inhibition of human recombinant 17beta-HSD1 expressed in HEK293 cell lysate assessed as conversion of radiolabeled estrone to estradiolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17290BDBM17290(EM1745 | E2-adenosine hybrid compound, 8 | [5-(6-a...)
Affinity DataKi:  3nM ΔG°:  -12.1kcal/molepH: 7.5 T: 2°CAssay Description:For steady-state kinetic study of hybrid inhibitors, a Fluorolog 3 instrument was used to monitor the fluorescent signal of NADPH formed during estra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2007
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50406414BDBM50406414(CHEMBL76061)
Affinity DataKi:  2.80E+3nMAssay Description:Tested by protection experiments to demonstrate the inactivation of estradiol dehydrogenase and the kinetic parameter Ki app was reported at a concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50400841BDBM50400841(CHEMBL2205681)
Affinity DataKi:  4.08E+3nMAssay Description:Inhibition of human estradiol 17beta-dehydrogenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17289BDBM17289(folliculin | (1S,10R,11S,15S)-5-hydroxy-15-methylt...)
Affinity DataKi:  9.50E+3nMAssay Description:Inhibition of human estradiol 17beta-dehydrogenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50400840BDBM50400840(CHEMBL2205682)
Affinity DataKi:  1.28E+4nMAssay Description:Inhibition of human estradiol 17beta-dehydrogenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 48630BDBM48630(SMR000058657 | cid_92895 | ESTRONE 3-METHYL ETHER ...)
Affinity DataKi:  2.40E+4nMAssay Description:Inhibition of human estradiol 17beta-dehydrogenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50015834BDBM50015834(CHEMBL307621 | Diastereomer-7-Methyl-7-(4,4,4-trif...)
Affinity DataKi:  5.90E+4nMAssay Description:Tested for time-dependent inactivation of the enzyme that followed pseudo- first- order kinetics in the absence of NAD+ and the Ki values were report...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50015835BDBM50015835(CHEMBL75893 | Diastereomer-7-Methyl-7-(4,4,4-trifl...)
Affinity DataKi:  6.50E+4nMAssay Description:Tested for time-dependent inactivation of the enzyme that followed pseudo- first- order kinetics in the absence of NAD+ and the Ki values were report...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50400839BDBM50400839(CHEMBL2205683)
Affinity DataKi:  6.94E+4nMAssay Description:Inhibition of human estradiol 17beta-dehydrogenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17293BDBM17293([5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-y...)
Affinity DataKi:  2.50E+5nM ΔG°:  -5.11kcal/molepH: 7.5 T: 2°CAssay Description:For steady-state kinetic study of hybrid inhibitors, a Fluorolog 3 instrument was used to monitor the fluorescent signal of NADPH formed during estra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2007
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Chuq-Pavillon Chul and Université

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50400838BDBM50400838(CHEMBL2205684)
Affinity DataKi:  4.25E+5nMAssay Description:Inhibition of human estradiol 17beta-dehydrogenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed