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Found 20 Enz. Inhib. hit(s) with all data for entry = 50030914
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303964((E)-3-(3-Methoxy-1,4-naphthoquinon-2-yl)-2-methylp...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303973((E)-N-(2-Hydroxyethyl)-3-(3-chloro-1,4-dioxonaphth...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303972((E)-3-(3-Bromo-1,4-naphthoquinon-2-yl)-2-methoxyet...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303967((E)-3-(3-Chloro-1,4-naphthoquinon-2-yl)-2-methylpr...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303965((E)-3-(3-Methylthio-1,4-naphthoquinon-2-yl)-2-meth...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303969((E)-3-(3-Bromo-1,4-naphthoquinon-2-yl)-2-methylpro...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303968((Z)-3-(3-Chloro-1,4-naphthoquinon-2-yl)-2-methylpr...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303959((E)-3-(3-Chloro-5,6-dimethoxy-1,4-dioxocyclohexa-2...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303957((E)-3-(5,6-Dimethoxy-3-methyl-1,4-dioxocyclohexa-2...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303962((E)-3-(1,4-Naphthoquinon-2-yl)-2-methylpropenoic a...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303971((E)-2-((3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303966((E)-3-(3-Fluoro-1,4-naphthoquinon-2-yl)-2-methylpr...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303974(3-(3-Bromo-1,4-naphthoquinon-2-yl)-propionic Acid ...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303970((E)-3-(3-Methyl-1,4-naphthoquinon-2-yl)-2-methoxye...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303955((E)-3-(5,6-Dimethoxy-3-methyl-14-dioxocyclohexa-25...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303960((E)-3-(5,6-Dimethoxy-3-methyl-1,4-dioxocyclohexa-2...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303961((E)-N-(2-Hydroxyethyl)-3-(5,6-dimethoxy-3-methyl-1...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303963((E)-3-(3-Methyl-1,4-naphthoquinon-2-yl)-2-methylpr...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303958((E)-3-(5,6-Dimethoxy-3-methyl-1,4-dioxocyclohexa-2...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50303956((E)-3-(5,6-Dimethoxy-3-methyl-1,4-dioxocyclohexa-2...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed