Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 447
TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 269485BDBM269485( (S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2...)
Affinity DataKi:  5.70nM ΔG°:  -47.1kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 269499BDBM269499((S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,...)
Affinity DataKi:  9nM ΔG°:  -45.9kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 269503BDBM269503((S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,...)
Affinity DataKi:  11nM ΔG°:  -45.4kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 269487BDBM269487((S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,...)
Affinity DataKi:  13nM ΔG°:  -45.0kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 269495BDBM269495((S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,...)
Affinity DataKi:  14nM ΔG°:  -44.8kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 269489BDBM269489((S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,...)
Affinity DataKi:  15nM ΔG°:  -44.7kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 269501BDBM269501((S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,...)
Affinity DataKi:  16nM ΔG°:  -44.5kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 269490BDBM269490((S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,...)
Affinity DataKi:  20nM ΔG°:  -43.9kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 269499BDBM269499((S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,...)
Affinity DataKi:  21nM ΔG°:  -43.8kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 269497BDBM269497((S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,...)
Affinity DataKi:  22nM ΔG°:  -43.7kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 269486BDBM269486((S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,...)
Affinity DataKi:  22nM ΔG°:  -43.7kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 269498BDBM269498((S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,...)
Affinity DataKi:  23nM ΔG°:  -43.6kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 269488BDBM269488((S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,...)
Affinity DataKi:  25nM ΔG°:  -43.4kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 269502BDBM269502((S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,...)
Affinity DataKi:  25nM ΔG°:  -43.4kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 269492BDBM269492((S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,...)
Affinity DataKi:  29nM ΔG°:  -43.0kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 269493BDBM269493((S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,...)
Affinity DataKi:  30nM ΔG°:  -42.9kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 269491BDBM269491((S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,...)
Affinity DataKi:  32nM ΔG°:  -42.8kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 269494BDBM269494((S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,...)
Affinity DataKi:  55nM ΔG°:  -41.4kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 269496BDBM269496((S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,...)
Affinity DataKi:  84nM ΔG°:  -40.4kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent