Compile Data Set for Download or QSAR
Report error Found 956 Enz. Inhib. hit(s) with all data for entry = 2741
TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378442BDBM378442(N-((1R,3R,5S)-8-(((1r,4R)-4-aminocyclohexyl)sulfon...)
Affinity DataIC50: 0.440nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378443BDBM378443(N-((1R,3r,5S)-8-((4-aminopiperidin-1-yl)sulfonyl)-...)
Affinity DataIC50: 0.490nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378444BDBM378444(N-((1R,3r,5S)-8-(((1-methylpiperidin-4-yl)methyl)s...)
Affinity DataIC50: 0.670nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378445BDBM378445(N-((1R,3r,5S)-8-((4-aminopiperidin-1-yl)sulfonyl)-...)
Affinity DataIC50: 0.680nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378446BDBM378446(N-((1R,3r,5S)-8-((4-aminopiperidin-1-yl)sulfonyl)-...)
Affinity DataIC50: 0.810nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378447BDBM378447(N-((2S,4S)-1-((4-aminopiperidin-1-yl)sulfonyl)-2-m...)
Affinity DataIC50: 0.900nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378448BDBM378448(N-((1R,3r,5S)-8-(((1-(3-hydroxypropyl)piperidin-4-...)
Affinity DataIC50: 0.950nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378449BDBM378449(N-((2S,4S)-1-((4-aminopiperidin-1-yl)sulfonyl)-2-m...)
Affinity DataIC50: 0.980nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378450BDBM378450(N-((1R,3R,5S)-8-(((1r,4R)-4-aminocyclohexyl)sulfon...)
Affinity DataIC50: 1.10nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetN-lysine methyltransferase SMYD2(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378746BDBM378746(US10266526, Compound 929 | N-(1-((1-(4-chlorobenzy...)
Affinity DataIC50: 1.20nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% Bovine Skin Gelatin, and 0.002% Tween20, prepared on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378451BDBM378451(N-((2S)-1-((4-(2-aminopropan-2-yl)phenyl)sulfonyl)...)
Affinity DataIC50: 1.47nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378452BDBM378452(6-chloro-N-((1R,3r,5S)-8-(((1-(3-hydroxypropyl)pip...)
Affinity DataIC50: 1.73nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378453BDBM378453(6-chloro-N-((1R,3r,5S)-8-((4-(methylamino)piperidi...)
Affinity DataIC50: 1.89nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378455BDBM378455(N-((2S,4S)-1-((4-(2-aminopropan-2-yl)phenyl)sulfon...)
Affinity DataIC50: 1.98nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378454BDBM378454(N-((1R,3r,5S)-8-((4-(benzylamino)piperidin-1-yl)su...)
Affinity DataIC50: 1.98nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378456BDBM378456(N-((1R,3r,5S)-8-((4-(methylamino)piperidin-1-yl)su...)
Affinity DataIC50: 2.13nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378457BDBM378457(2-oxo-N-((1R,3r,5S)-8-((piperidin-3-ylmethyl)sulfo...)
Affinity DataIC50: 2.14nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378458BDBM378458(N-((1R,3R,5S)-8-(((1s,4S)-4-aminocyclohexyl)sulfon...)
Affinity DataIC50: 2.33nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378459BDBM378459(N-((1R,3r,5S)-8-((4-(benzylamino)piperidin-1-yl)su...)
Affinity DataIC50: 2.58nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378460BDBM378460(N-((1R,3r,5S)-8-((4-(dimethylamino)piperidin-1-yl)...)
Affinity DataIC50: 2.89nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetN-lysine methyltransferase SMYD2(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378747BDBM378747(US10266526, Compound 930 | N-(1-((1-(4-chlorobenzy...)
Affinity DataIC50: 3.30nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% Bovine Skin Gelatin, and 0.002% Tween20, prepared on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378461BDBM378461(6-chloro-N-((1R,3r,5S)-8-((4-(dimethylamino)piperi...)
Affinity DataIC50: 3.46nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378462BDBM378462(6-chloro-2-oxo-N-((1R,3r,5S)-8-(((1-(4,4,4-trifluo...)
Affinity DataIC50: 3.54nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378463BDBM378463(6-chloro-2-oxo-N-((1R,3r,5S)-8-((piperidin-4-ylmet...)
Affinity DataIC50: 3.60nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetN-lysine methyltransferase SMYD2(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378802BDBM378802(US10266526, Compound 985 | N-(1-((1-(4-chlorobenzy...)
Affinity DataIC50: 3.90nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% Bovine Skin Gelatin, and 0.002% Tween20, prepared on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378464BDBM378464(US10266526, Compound 597 | 2-oxo-N-((1R,3r,5S)-8-(...)
Affinity DataIC50: 3.98nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378465BDBM378465(US10266526, Compound 598 | 6-chloro-2-oxo-N-((1R,3...)
Affinity DataIC50: 4.12nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378466BDBM378466(US10266526, Compound 599 | N-((2S,4S)-2-methyl-1-(...)
Affinity DataIC50: 4.42nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378465BDBM378465(US10266526, Compound 598 | 6-chloro-2-oxo-N-((1R,3...)
Affinity DataIC50: 4.99nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378468BDBM378468(US10266526, Compound 601 | 2-oxo-N-((1R,3r,5S)-8-(...)
Affinity DataIC50: 5.21nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378469BDBM378469(US10266526, Compound 602 | N-((1R,3r,5S)-8-((4-ami...)
Affinity DataIC50: 7.12nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetN-lysine methyltransferase SMYD2(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378750BDBM378750(US10266526, Compound 933 | N-(1-((1-benzyl-1H-pyra...)
Affinity DataIC50: 7.80nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% Bovine Skin Gelatin, and 0.002% Tween20, prepared on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378470BDBM378470(US10266526, Compound 603 | N-((3S)-1-((4-aminopipe...)
Affinity DataIC50: 8.53nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetN-lysine methyltransferase SMYD2(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378744BDBM378744(US10266526, Compound 927 | N-(1-((1-(4-chlorobenzy...)
Affinity DataIC50: 11nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% Bovine Skin Gelatin, and 0.002% Tween20, prepared on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetN-lysine methyltransferase SMYD2(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378783BDBM378783(US10266526, Compound 966 | N-(1-((1-benzyl-1H-pyra...)
Affinity DataIC50: 13nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% Bovine Skin Gelatin, and 0.002% Tween20, prepared on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378471BDBM378471(US10266526, Compound 604 | N-((1R,3r,5S)-8-((4-ami...)
Affinity DataIC50: 13.5nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetN-lysine methyltransferase SMYD2(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378760BDBM378760(US10266526, Compound 943 | 1-cyclopropyl-N-(1-((1-...)
Affinity DataIC50: 14nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% Bovine Skin Gelatin, and 0.002% Tween20, prepared on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378472BDBM378472(US10266526, Compound 605 | N-((2S,4S)-1-((4-aminop...)
Affinity DataIC50: 15.4nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378473BDBM378473(US10266526, Compound 606 | N-((1R,3r,5S)-8-((4-ami...)
Affinity DataIC50: 15.6nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetN-lysine methyltransferase SMYD2(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378810BDBM378810(US10266526, Compound 993 | 1-cyclopropyl-N-(1-((1-...)
Affinity DataIC50: 16nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% Bovine Skin Gelatin, and 0.002% Tween20, prepared on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetN-lysine methyltransferase SMYD2(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378654BDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 16.4nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% Bovine Skin Gelatin, and 0.002% Tween20, prepared on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378474BDBM378474(US10266526, Compound 607 | N-((2S,4S)-1-((4-aminop...)
Affinity DataIC50: 18.1nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378511BDBM378511(US10266526, Compound 644 | N-((1R,3r,5S)-8-((4-ami...)
Affinity DataIC50: 18.5nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378475BDBM378475(US10266526, Compound 608 | N-((3R,4R)-1-((4-aminop...)
Affinity DataIC50: 21.4nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetN-lysine methyltransferase SMYD2(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378768BDBM378768(US10266526, Compound 951 | 1-cyclopropyl-N-(1-((1-...)
Affinity DataIC50: 22nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% Bovine Skin Gelatin, and 0.002% Tween20, prepared on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378476BDBM378476(US10266526, Compound 609 | N-((1R,3r,5S)-8-((4-ami...)
Affinity DataIC50: 23.7nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378477BDBM378477(US10266526, Compound 610 | N-((1R,3r,5S)-8-((4-ami...)
Affinity DataIC50: 23.8nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetN-lysine methyltransferase SMYD2(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378804BDBM378804(US10266526, Compound 987 | N-(1-((1-(3-chlorobenzy...)
Affinity DataIC50: 24nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% Bovine Skin Gelatin, and 0.002% Tween20, prepared on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378478BDBM378478(US10266526, Compound 611 | 1-methyl-2-oxo-N-((1R,3...)
Affinity DataIC50: 25.9nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetN-lysine methyltransferase SMYD2(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378698BDBM378698(US10266526, Compound 836 | N-(1-{1-[4-(benzyloxy)p...)
Affinity DataIC50: 26.5nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% Bovine Skin Gelatin, and 0.002% Tween20, prepared on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

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