Compile Data Set for Download or QSAR
Report error Found 64 Enz. Inhib. hit(s) with all data for entry = 2759
TargetDNA topoisomerase 1(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259242BDBM50259242(CHEMBL4072011 | US10266550, Compound 11e)
Affinity DataIC50: 240nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259247BDBM50259247(CHEMBL4065223 | US10266550, Compound 11g)
Affinity DataIC50: 240nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259215BDBM50259215(CHEMBL4064887 | US10266550, Compound 11b)
Affinity DataIC50: 240nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259244BDBM50259244(CHEMBL4076393 | US10266550, Compound 16)
Affinity DataIC50: 480nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259214BDBM50259214(CHEMBL4061346 | US10266550, Compound 11a)
Affinity DataIC50: 480nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259247BDBM50259247(CHEMBL4065223 | US10266550, Compound 11g)
Affinity DataIC50: 480nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259221BDBM50259221(CHEMBL4097472 | US10266550, Compound 11d)
Affinity DataIC50: 480nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259245BDBM50259245(CHEMBL4064127 | US10266550, Compound 17a)
Affinity DataIC50: 725nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259248BDBM50259248(CHEMBL4104625 | US10266550, Compound 17bbSelectivi...)
Affinity DataIC50: 725nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259221BDBM50259221(CHEMBL4097472 | US10266550, Compound 11d)
Affinity DataIC50: 970nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259242BDBM50259242(CHEMBL4072011 | US10266550, Compound 11e)
Affinity DataIC50: 970nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259212BDBM50259212(CHEMBL2002459 | US10266550, Compound 1)
Affinity DataIC50: 1.95E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259246BDBM50259246(CHEMBL4066307 | US10266550, Compound 10a)
Affinity DataIC50: 1.95E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259246BDBM50259246(CHEMBL4066307 | US10266550, Compound 10a)
Affinity DataIC50: 1.95E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 2-alpha(Human)
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259244BDBM50259244(CHEMBL4076393 | US10266550, Compound 16)
Affinity DataIC50: 2.93E+3nMAssay Description:Human Topoisomerase IIα assays were carried out by adding the compounds to 185 ng of kinetoplast DNA (kDNA, from TopoGen) in the buffer supplied...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 2-alpha(Human)
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259247BDBM50259247(CHEMBL4065223 | US10266550, Compound 11g)
Affinity DataIC50: 2.93E+3nMAssay Description:Human Topoisomerase IIα assays were carried out by adding the compounds to 185 ng of kinetoplast DNA (kDNA, from TopoGen) in the buffer supplied...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 2-alpha(Human)
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259215BDBM50259215(CHEMBL4064887 | US10266550, Compound 11b)
Affinity DataIC50: 2.93E+3nMAssay Description:Human Topoisomerase IIα assays were carried out by adding the compounds to 185 ng of kinetoplast DNA (kDNA, from TopoGen) in the buffer supplied...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259242BDBM50259242(CHEMBL4072011 | US10266550, Compound 11e)
Affinity DataIC50: 3.90E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Human)
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259245BDBM50259245(CHEMBL4064127 | US10266550, Compound 17a)
Affinity DataIC50: 3.90E+3nMAssay Description:Human topoisomerase I relaxation assays were carried out with 0.5 U of enzyme in reaction buffer supplied by the manufacturer. The enzyme was mixed w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA gyrase subunit B(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259245BDBM50259245(CHEMBL4064127 | US10266550, Compound 17a)
Affinity DataIC50: 3.90E+3nMAssay Description:DNA gyrase supercoiling assays were carried out by mixing the compounds and the enzyme in a similar manner as above (EcTopI relaxation inhibition ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 379468BDBM379468(US10266550, Compound 11c)
Affinity DataIC50: 3.90E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 2-alpha(Human)
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259248BDBM50259248(CHEMBL4104625 | US10266550, Compound 17bbSelectivi...)
Affinity DataIC50: 3.90E+3nMAssay Description:Human Topoisomerase IIα assays were carried out by adding the compounds to 185 ng of kinetoplast DNA (kDNA, from TopoGen) in the buffer supplied...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Human)
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259248BDBM50259248(CHEMBL4104625 | US10266550, Compound 17bbSelectivi...)
Affinity DataIC50: 3.90E+3nMAssay Description:Human topoisomerase I relaxation assays were carried out with 0.5 U of enzyme in reaction buffer supplied by the manufacturer. The enzyme was mixed w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA gyrase subunit B(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259248BDBM50259248(CHEMBL4104625 | US10266550, Compound 17bbSelectivi...)
Affinity DataIC50: 3.90E+3nMAssay Description:DNA gyrase supercoiling assays were carried out by mixing the compounds and the enzyme in a similar manner as above (EcTopI relaxation inhibition ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 379478BDBM379478(US10266550, Compound 15a)
Affinity DataIC50: 3.90E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 379465BDBM379465(US10266550, Compound 10b)
Affinity DataIC50: 3.90E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA gyrase subunit B(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259244BDBM50259244(CHEMBL4076393 | US10266550, Compound 16)
Affinity DataIC50: 3.90E+3nMAssay Description:DNA gyrase supercoiling assays were carried out by mixing the compounds and the enzyme in a similar manner as above (EcTopI relaxation inhibition ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Human)
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259247BDBM50259247(CHEMBL4065223 | US10266550, Compound 11g)
Affinity DataIC50: 3.90E+3nMAssay Description:Human topoisomerase I relaxation assays were carried out with 0.5 U of enzyme in reaction buffer supplied by the manufacturer. The enzyme was mixed w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 379475BDBM379475(US10266550, Compound 11j)
Affinity DataIC50: 3.90E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 379474BDBM379474(US10266550, Compound 11i)
Affinity DataIC50: 3.90E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 379471BDBM379471(US10266550, Compound 11f)
Affinity DataIC50: 5.85E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 2-alpha(Human)
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259214BDBM50259214(CHEMBL4061346 | US10266550, Compound 11a)
Affinity DataIC50: 5.85E+3nMAssay Description:Human Topoisomerase IIα assays were carried out by adding the compounds to 185 ng of kinetoplast DNA (kDNA, from TopoGen) in the buffer supplied...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 2-alpha(Human)
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259242BDBM50259242(CHEMBL4072011 | US10266550, Compound 11e)
Affinity DataIC50: 5.85E+3nMAssay Description:Human Topoisomerase IIα assays were carried out by adding the compounds to 185 ng of kinetoplast DNA (kDNA, from TopoGen) in the buffer supplied...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA gyrase subunit B(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259221BDBM50259221(CHEMBL4097472 | US10266550, Compound 11d)
Affinity DataIC50: 7.80E+3nMAssay Description:DNA gyrase supercoiling assays were carried out by mixing the compounds and the enzyme in a similar manner as above (EcTopI relaxation inhibition ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 379477BDBM379477(US10266550, Compound 12)
Affinity DataIC50: 7.80E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Human)
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259244BDBM50259244(CHEMBL4076393 | US10266550, Compound 16)
Affinity DataIC50: 7.80E+3nMAssay Description:Human topoisomerase I relaxation assays were carried out with 0.5 U of enzyme in reaction buffer supplied by the manufacturer. The enzyme was mixed w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Human)
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259215BDBM50259215(CHEMBL4064887 | US10266550, Compound 11b)
Affinity DataIC50: 7.80E+3nMAssay Description:Human topoisomerase I relaxation assays were carried out with 0.5 U of enzyme in reaction buffer supplied by the manufacturer. The enzyme was mixed w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA gyrase subunit B(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259215BDBM50259215(CHEMBL4064887 | US10266550, Compound 11b)
Affinity DataIC50: 1.17E+4nMAssay Description:DNA gyrase supercoiling assays were carried out by mixing the compounds and the enzyme in a similar manner as above (EcTopI relaxation inhibition ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Human)
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259242BDBM50259242(CHEMBL4072011 | US10266550, Compound 11e)
Affinity DataIC50: 1.17E+4nMAssay Description:Human topoisomerase I relaxation assays were carried out with 0.5 U of enzyme in reaction buffer supplied by the manufacturer. The enzyme was mixed w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 2-alpha(Human)
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259221BDBM50259221(CHEMBL4097472 | US10266550, Compound 11d)
Affinity DataIC50: 1.56E+4nMAssay Description:Human Topoisomerase IIα assays were carried out by adding the compounds to 185 ng of kinetoplast DNA (kDNA, from TopoGen) in the buffer supplied...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Human)
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259221BDBM50259221(CHEMBL4097472 | US10266550, Compound 11d)
Affinity DataIC50: 1.56E+4nMAssay Description:Human topoisomerase I relaxation assays were carried out with 0.5 U of enzyme in reaction buffer supplied by the manufacturer. The enzyme was mixed w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 379476BDBM379476(US10266550, Compound 11k)
Affinity DataIC50: 1.56E+4nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA gyrase subunit B(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259247BDBM50259247(CHEMBL4065223 | US10266550, Compound 11g)
Affinity DataIC50: 1.56E+4nMAssay Description:DNA gyrase supercoiling assays were carried out by mixing the compounds and the enzyme in a similar manner as above (EcTopI relaxation inhibition ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 379123BDBM379123(US10266550, Compound 6a | Ethyl 5,6-difluoro-9-nit...)
Affinity DataIC50: 1.56E+4nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Human)
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259214BDBM50259214(CHEMBL4061346 | US10266550, Compound 11a)
Affinity DataIC50: 1.56E+4nMAssay Description:Human topoisomerase I relaxation assays were carried out with 0.5 U of enzyme in reaction buffer supplied by the manufacturer. The enzyme was mixed w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 379458BDBM379458(5, 6-Difluoro-9-nitro-3-oxo-3H-pyrido[3, 2,1-kl]ph...)
Affinity DataIC50: 1.56E+4nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 379461BDBM379461(US10266550, Compound 7d)
Affinity DataIC50: 1.56E+4nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA gyrase subunit B(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259242BDBM50259242(CHEMBL4072011 | US10266550, Compound 11e)
Affinity DataIC50: 2.34E+4nMAssay Description:DNA gyrase supercoiling assays were carried out by mixing the compounds and the enzyme in a similar manner as above (EcTopI relaxation inhibition ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA gyrase subunit B(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 50259214BDBM50259214(CHEMBL4061346 | US10266550, Compound 11a)
Affinity DataIC50: 2.34E+4nMAssay Description:DNA gyrase supercoiling assays were carried out by mixing the compounds and the enzyme in a similar manner as above (EcTopI relaxation inhibition ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandChemical structure of BindingDB Monomer ID 379133BDBM379133(US10266550, Compound 6b | Ethyl 9-cyano-5, 6-diflu...)
Affinity DataIC50: 3.13E+4nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

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