Compile Data Set for Download or QSAR
Report error Found 29 Enz. Inhib. hit(s) with all data for entry = 50011441
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17659(pentanedioic acid analogue, (RS)-1 | 2-(phosphonom...)
Affinity DataIC50: 0.300nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50085699(2-[(2,4-Dicarboxy-butyl)-hydroxy-phosphinoylmethyl...)
Affinity DataIC50: 0.5nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106576(2-[(2-Carboxy-propyl)-hydroxy-phosphinoylmethyl]-p...)
Affinity DataIC50: 1.5nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106577(2-[(2-Carboxy-3-phenyl-propyl)-hydroxy-phosphinoyl...)
Affinity DataIC50: 2nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106570(2-{Hydroxy-[(4-methoxy-phenylamino)-methyl]-phosph...)
Affinity DataIC50: 3nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106566(2-(Hydroxy-phenylaminomethyl-phosphinoylmethyl)-pe...)
Affinity DataIC50: 4nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106575(2-[Hydroxy-(hydroxy-pyridin-4-yl-methyl)-phosphino...)
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106567(2-{[(3-Fluoro-phenyl)-hydroxy-methyl]-hydroxy-phos...)
Affinity DataIC50: 16nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106564(2-[(3,5-Difluoro-benzyl)-hydroxy-phosphinoylmethyl...)
Affinity DataIC50: 49nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106568(2-(Benzyl-hydroxy-phosphinoylmethyl)-pentanedioic ...)
Affinity DataIC50: 53nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106560(2-[(3,5-Bis-trifluoromethyl-benzyl)-hydroxy-phosph...)
Affinity DataIC50: 55nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106557(2-[Hydroxy-(hydroxy-phenyl-methyl)-phosphinoylmeth...)
Affinity DataIC50: 55nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106571(2-[(Benzylamino-methyl)-hydroxy-phosphinoylmethyl]...)
Affinity DataIC50: 59nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106555(2-[Hydroxy-(4-methyl-benzyl)-phosphinoylmethyl]-pe...)
Affinity DataIC50: 68nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17752(CHEMBL64901 | 2-({hydroxy[(2,3,4,5,6-pentafluoroph...)
Affinity DataIC50: 82nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106572(2-[Hydroxy-(4-methoxy-benzyl)-phosphinoylmethyl]-p...)
Affinity DataIC50: 90nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106558(2-[(2-Benzyloxycarbonyl-propyl)-hydroxy-phosphinoy...)
Affinity DataIC50: 95nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106563(2-[(3-Amino-benzyl)-hydroxy-phosphinoylmethyl]-pen...)
Affinity DataIC50: 143nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106578(2-(Hydroxy-phenethyl-phosphinoylmethyl)-pentanedio...)
Affinity DataIC50: 149nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106565(2-[(2-Fluoro-benzyl)-hydroxy-phosphinoylmethyl]-pe...)
Affinity DataIC50: 156nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106554(2-Phosphonomethyl-4-(5H-tetrazol-5-yl)-butyric aci...)
Affinity DataIC50: 175nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106556(2-Phosphonomethyl-hexanedioic acid | CHEMBL334737)
Affinity DataIC50: 185nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106562(4-Phenyl-2-phosphonomethyl-butyric acid | CHEMBL13...)
Affinity DataIC50: 199nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106559(4-Cyano-2-phosphonomethyl-butyric acid | CHEMBL334...)
Affinity DataIC50: 335nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106561(2-(Hydroxy-propyl-phosphinoylmethyl)-pentanedioic ...)
Affinity DataIC50: 360nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106574(2-(3-Hydroxy-benzyl)-3-phosphono-propionic acid | ...)
Affinity DataIC50: 508nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106569(2-Benzyl-3-phosphono-propionic acid | CHEMBL132313)
Affinity DataIC50: 548nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048693(2-Phosphonomethyl-succinic acid | 2-Phosphonomethy...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Rat)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106573(2-(Hydroxy-phenyl-phosphinoylmethyl)-pentanedioic ...)
Affinity DataIC50: 2.93E+3nMAssay Description:Inhibitory concentration against rat brain NAALADase (Folate hydrolase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed