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Found 26 Enz. Inhib. hit(s) with all data for entry = 50035218
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50366780(BMS-189090 | CHEMBL138877)
Affinity DataKi:  3.40nMAssay Description:In vitro reversible inhibition of thrombin catalytic activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107445((S)-4-((S)-2-{[((S)-1-Carbamimidoyl-piperidine-3-c...)
Affinity DataIC50:  12nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107455(4-Carbamimidoyl-N-{(S)-1-[(S)-3-hydroxy-2-(naphtha...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50366780(BMS-189090 | CHEMBL138877)
Affinity DataIC50:  16nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50366780(BMS-189090 | CHEMBL138877)
Affinity DataIC50:  16nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50228863((S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrro...)
Affinity DataIC50:  18nMAssay Description:In vitro inhibition of thrombin catalytic activity using s-2238 substrate at 10 uM was measured at rt after 3 min incubation with compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107446(1-Carbamimidoyl-piperidine-3-carboxylic acid {(S)-...)
Affinity DataIC50:  32nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50038001((2R,4R)-1-((S)-5-(diaminomethyleneamino)-2-(3-meth...)
Affinity DataIC50:  38nMAssay Description:In vitro inhibition of thrombin catalytic activity using s-2238 substrate at 10 uM was measured at rat after 3 min incubation with compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107442(6-Guanidino-hexanoic acid {(S)-1-[(S)-3-hydroxy-2-...)
Affinity DataIC50:  50nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107434(1-Carbamimidoyl-piperidine-3-carboxylic acid {(S)-...)
Affinity DataIC50:  75nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107453(5-Guanidino-pentanoic acid {(S)-1-[(S)-3-hydroxy-2...)
Affinity DataIC50:  80nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107449(1-Carbamimidoyl-piperidine-4-carboxylic acid {(S)-...)
Affinity DataIC50:  110nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107447(2-(1-Carbamimidoyl-piperidin-4-yl)-N-{(S)-1-[(S)-3...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107439(1-Carbamimidoyl-piperidine-3-carboxylic acid {(S)-...)
Affinity DataIC50:  310nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107444(4-Guanidino-N-{(S)-1-[(S)-3-hydroxy-2-(naphthalene...)
Affinity DataIC50:  390nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107450((R)-1-Carbamimidoyl-piperidine-3-carboxylic acid {...)
Affinity DataIC50:  500nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50451350(CHEMBL2111938)
Affinity DataIC50:  500nMAssay Description:In vitro inhibition of thrombin catalytic activity using s-2238 substrate at 10 uM was measured at rat after 3 min incubation with compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107441((2S,4S)-1-[(S)-3-Hydroxy-2-(naphthalene-2-sulfonyl...)
Affinity DataIC50:  620nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107448(1-Carbamimidoyl-piperidine-3-carboxylic acid {(S)-...)
Affinity DataIC50:  650nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107440(CHEMBL136076 | Naphthalene-2-sulfonic acid {(S)-2-...)
Affinity DataIC50:  1.40E+3nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107451((2R,4R)-1-[(S)-3-Hydroxy-2-(naphthalene-2-sulfonyl...)
Affinity DataIC50:  1.70E+3nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107438((S)-1-[(S)-3-Hydroxy-2-(naphthalene-2-sulfonylamin...)
Affinity DataIC50:  2.80E+3nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107443((2S,4S)-4-Methyl-1-[2-(naphthalene-2-sulfonylamino...)
Affinity DataIC50:  2.90E+3nMAssay Description:In vitro inhibition of thrombin catalytic activity using s-2238 substrate at 10 uM was measured at rt after 3 min incubation with compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107436(CHEMBL344825 | Naphthalene-2-sulfonic acid {(S)-2-...)
Affinity DataIC50:  7.40E+3nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107454(7-Guanidino-heptanoic acid {(S)-1-[(S)-3-hydroxy-2...)
Affinity DataIC50:  1.40E+4nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50107437((2R,4R)-4-Methyl-1-[2-(naphthalene-2-sulfonylamino...)
Affinity DataIC50:  2.70E+4nMAssay Description:In vitro inhibition of human thrombin catalytic activity after 3 min pre incubation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed