Compile Data Set for Download or QSAR
maximum 50k data
Found 35 Enz. Inhib. hit(s) with all data for entry = 50014129
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138515(1-(7-Hydroxy-naphthalen-1-yl)-3-(4-trifluoromethyl...)
Affinity DataKi:  1nMAssay Description:Binding affinity towards cloned human vanilloid receptor subtype 1 in HEK293 cell membranes using [3H]-RTX as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138518(1-(7-Hydroxy-naphthalen-1-yl)-3-(4-trifluoromethox...)
Affinity DataKi:  1nMAssay Description:Functional antagonistic activity against human vanilloid receptor subtype 1 in HEK293 cell membranes was determined as inhibition of agonist-induced ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138503(1-[2-(3,4-Dichloro-phenyl)-ethyl]-3-(7-hydroxy-nap...)
Affinity DataKi:  1nMAssay Description:Functional antagonistic activity against human vanilloid receptor subtype 1 in HEK293 cell membranes was determined as inhibition of agonist-induced ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138514(1-(3,4-Dichloro-benzyl)-3-(7-hydroxy-naphthalen-1-...)
Affinity DataKi:  2nMAssay Description:Functional antagonistic activity against human vanilloid receptor subtype 1 in HEK293 cell membranes was determined as inhibition of agonist-induced ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138506(1-(7-Hydroxy-naphthalen-1-yl)-3-(3-trifluoromethyl...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity towards cloned human vanilloid receptor subtype 1 in HEK293 cell membranes using [3H]-RTX as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138512(1-(2,4-Dichloro-benzyl)-3-(7-hydroxy-naphthalen-1-...)
Affinity DataKi:  2.80nMAssay Description:Binding affinity towards cloned human vanilloid receptor subtype 1 in HEK293 cell membranes using [3H]-RTX as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138516(1-(7-Hydroxy-naphthalen-1-yl)-3-[1-(4-trifluoromet...)
Affinity DataKi:  4nMAssay Description:Binding affinity towards cloned human vanilloid receptor subtype 1 in HEK293 cell membranes using [3H]-RTX as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138519(3-(3,4-Dichloro-phenyl)-N-(7-hydroxy-naphthalen-1-...)
Affinity DataKi:  4.60nMAssay Description:Binding affinity towards cloned human vanilloid receptor subtype 1 in HEK293 cell membranes using [3H]-RTX as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138504(1-(3,4-Difluoro-benzyl)-3-(7-hydroxy-naphthalen-1-...)
Affinity DataKi:  7nMAssay Description:Binding affinity towards cloned human vanilloid receptor subtype 1 in HEK293 cell membranes using [3H]-RTX as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138508(3-(4-Chloro-phenyl)-N-(7-hydroxy-naphthalen-1-yl)-...)
Affinity DataKi:  9.80nMAssay Description:Binding affinity towards cloned human vanilloid receptor subtype 1 in HEK293 cell membranes using [3H]-RTX as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138511(1-(7-Hydroxy-naphthalen-1-yl)-3-phenethyl-urea | C...)
Affinity DataKi:  53nMAssay Description:Binding affinity towards cloned human vanilloid receptor subtype 1 in HEK293 cell membranes using [3H]-RTX as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM6650(1-benzyl-3-(7-hydroxynaphthalen-1-yl)urea | CHEMBL...)
Affinity DataKi:  94nMAssay Description:Binding affinity towards cloned human vanilloid receptor subtype 1 in HEK293 cell membranes using [3H]-RTX as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM20284(CHEMBL391997 | CPZ | Capsazepine | N-[2-(4-chlorop...)
Affinity DataKi:  120nMAssay Description:Binding affinity towards cloned human vanilloid receptor subtype 1 in HEK293 cell membranes using [3H]-RTX as radioligandMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138510(1-(3,4-Dichloro-benzyl)-3-(7-hydroxy-naphthalen-1-...)
Affinity DataKi:  581nMAssay Description:Binding affinity towards cloned human vanilloid receptor subtype 1 in HEK293 cell membranes using [3H]-RTX as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138513(1-Benzyl-1-ethyl-3-(7-hydroxy-naphthalen-1-yl)-ure...)
Affinity DataKi:  1.11E+3nMAssay Description:Binding affinity towards cloned human vanilloid receptor subtype 1 in HEK293 cell membranes using [3H]-RTX as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138502(2-(3,4-Dichloro-phenyl)-N-(7-hydroxy-naphthalen-1-...)
Affinity DataKi:  1.83E+3nMAssay Description:Binding affinity towards cloned human vanilloid receptor subtype 1 in HEK293 cell membranes using [3H]-RTX as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138517(1,1-Dibenzyl-3-(7-hydroxy-naphthalen-1-yl)-urea | ...)
Affinity DataKi:  3.28E+3nMAssay Description:Binding affinity towards cloned human vanilloid receptor subtype 1 in HEK293 cell membranes using [3H]-RTX as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138507((7-Hydroxy-naphthalen-1-yl)-carbamic acid phenyl e...)
Affinity DataKi: >1.00E+4nMAssay Description:Dislacement of [3H]-RTX binding to human vanilloid receptor subtype 1 expressed in HEK293 cell membranes (inactive)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138509(1-Benzyl-3-(7-hydroxy-naphthalen-1-yl)-1-methyl-ur...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity towards cloned human vanilloid receptor subtype 1 in HEK293 cell membranes using [3H]-RTX as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138515(1-(7-Hydroxy-naphthalen-1-yl)-3-(4-trifluoromethyl...)
Affinity DataIC50:  4nMAssay Description:Functional antagonistic activity against human vanilloid receptor subtype 1 in HEK293 cell membranes was determined as inhibition of agonist-induced ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138514(1-(3,4-Dichloro-benzyl)-3-(7-hydroxy-naphthalen-1-...)
Affinity DataIC50:  15nMAssay Description:Functional antagonistic activity against human vanilloid receptor subtype 1 in HEK293 cell membranes was determined as inhibition of agonist-induced ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138519(3-(3,4-Dichloro-phenyl)-N-(7-hydroxy-naphthalen-1-...)
Affinity DataIC50:  17nMAssay Description:Functional antagonistic activity against human vanilloid receptor subtype 1 in HEK293 cell membranes was determined as inhibition of agonist-induced ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138508(3-(4-Chloro-phenyl)-N-(7-hydroxy-naphthalen-1-yl)-...)
Affinity DataIC50:  21nMAssay Description:Functional antagonistic activity against human vanilloid receptor subtype 1 in HEK293 cell membranes was determined as inhibition of agonist-induced ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138506(1-(7-Hydroxy-naphthalen-1-yl)-3-(3-trifluoromethyl...)
Affinity DataIC50:  26nMAssay Description:Functional antagonistic activity against human vanilloid receptor subtype 1 in HEK293 cell membranes was determined as inhibition of agonist-induced ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138518(1-(7-Hydroxy-naphthalen-1-yl)-3-(4-trifluoromethox...)
Affinity DataIC50:  27nMAssay Description:Functional antagonistic activity against human vanilloid receptor subtype 1 in HEK293 cell membranes was determined as inhibition of agonist-induced ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM6650(1-benzyl-3-(7-hydroxynaphthalen-1-yl)urea | CHEMBL...)
Affinity DataIC50:  45nMAssay Description:Dislacement of [3H]-RTX binding to human vanilloid receptor subtype 1 expressed in HEK293 cell membranes (inactive)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138503(1-[2-(3,4-Dichloro-phenyl)-ethyl]-3-(7-hydroxy-nap...)
Affinity DataIC50:  90nMAssay Description:Functional antagonistic activity against human vanilloid receptor subtype 1 in HEK293 cell membranes was determined as inhibition of agonist-induced ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM20284(CHEMBL391997 | CPZ | Capsazepine | N-[2-(4-chlorop...)
Affinity DataIC50:  100nMAssay Description:Binding affinity towards cloned human vanilloid receptor subtype 1 in HEK293 cell membranes using [3H]-RTX as radioligandMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138520(4-Chloro-N-(7-hydroxy-naphthalen-1-yl)-benzamide |...)
Affinity DataIC50:  320nMAssay Description:Functional antagonistic activity against human vanilloid receptor subtype 1 in HEK293 cell membranes was determined as inhibition of agonist-induced ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138502(2-(3,4-Dichloro-phenyl)-N-(7-hydroxy-naphthalen-1-...)
Affinity DataIC50:  770nMAssay Description:Functional antagonistic activity against human vanilloid receptor subtype 1 in HEK293 cell membranes was determined as inhibition of agonist-induced ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138507((7-Hydroxy-naphthalen-1-yl)-carbamic acid phenyl e...)
Affinity DataIC50:  6.30E+3nMAssay Description:Binding affinity towards cloned human vanilloid receptor subtype 1 in HEK293 cell membranes using [3H]-RTX as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138517(1,1-Dibenzyl-3-(7-hydroxy-naphthalen-1-yl)-urea | ...)
Affinity DataIC50: >1.00E+4nMAssay Description:Increased [Ca2+] influx in HEK293 cell membranes expressing human vanilloid receptor subtype 1 (inactive)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138513(1-Benzyl-1-ethyl-3-(7-hydroxy-naphthalen-1-yl)-ure...)
Affinity DataIC50: >1.00E+4nMAssay Description:Increased [Ca2+] influx in HEK293 cell membranes expressing human vanilloid receptor subtype 1 (inactive)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138509(1-Benzyl-3-(7-hydroxy-naphthalen-1-yl)-1-methyl-ur...)
Affinity DataIC50: >1.00E+4nMAssay Description:Increased [Ca2+] influx in HEK293 cell membranes expressing human vanilloid receptor subtype 1 (inactive)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50138505(CHEMBL150689 | Thiomorpholine-4-carboxylic acid [2...)
Affinity DataEC50:  390nMAssay Description:Increased [Ca2+] influx in HEK293 cell membranes expressing human vanilloid receptor subtype 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed