Compile Data Set for Download or QSAR
Report error Found 44 Enz. Inhib. hit(s) with all data for entry = 50014756
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50147047BDBM50147047(5-Methylsulfanyl-4-[4-(1-phenyl-5-propyl-1H-pyrazo...)
Affinity DataKi:  60nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50147046BDBM50147046(5-Methylsulfanyl-4-[4-(5-propoxy-1-pyridin-2-yl-1H...)
Affinity DataKi:  70nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50147059BDBM50147059(4-[4-(5-Ethoxy-1-phenyl-1H-pyrazol-4-yl)-thiazol-2...)
Affinity DataKi:  90nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50147054BDBM50147054(5-Methylsulfanyl-4-[4-(1-phenyl-1H-pyrazol-4-yl)-t...)
Affinity DataKi:  150nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50147046BDBM50147046(5-Methylsulfanyl-4-[4-(5-propoxy-1-pyridin-2-yl-1H...)
Affinity DataKi:  180nMAssay Description:In vitro binding affinity towards trypsin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50147056BDBM50147056(4-[4-(1-Methyl-3-propyl-1H-pyrazol-4-yl)-thiazol-2...)
Affinity DataKi:  190nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50147046BDBM50147046(5-Methylsulfanyl-4-[4-(5-propoxy-1-pyridin-2-yl-1H...)
Affinity DataIC50: 300nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50147051BDBM50147051(4-[4-(1-Methyl-5-propyl-1H-pyrazol-4-yl)-thiazol-2...)
Affinity DataKi:  330nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099897BDBM50099897(5-Methylsulfanyl-4-(4-p-tolyl-thiazol-2-yl)-thioph...)
Affinity DataKi:  420nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099900BDBM50099900(4-[4-(4-Chloro-phenyl)-thiazol-2-yl]-5-methylsulfa...)
Affinity DataKi:  436nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099935BDBM50099935(4-(4-Benzo[b]thiophen-3-yl-thiazol-2-yl)-5-methyls...)
Affinity DataKi:  450nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50147050BDBM50147050(4-[4-(1-Methyl-1H-pyrazol-4-yl)-thiazol-2-yl]-5-me...)
Affinity DataKi:  460nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099903BDBM50099903(4-[4-(3-Methoxy-phenyl)-thiazol-2-yl]-5-methylsulf...)
Affinity DataKi:  470nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099936BDBM50099936(5-Methylsulfanyl-4-(4-naphthalen-2-yl-thiazol-2-yl...)
Affinity DataKi:  490nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099937BDBM50099937(5-Methylsulfanyl-4-(4-phenoxymethyl-thiazol-2-yl)-...)
Affinity DataKi:  520nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50147058BDBM50147058(4-[4-(5-Cyclobutylmethoxy-1-phenyl-1H-pyrazol-4-yl...)
Affinity DataKi:  530nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099921BDBM50099921(5-Methylsulfanyl-4-(4-phenyl-thiazol-2-yl)-thiophe...)
Affinity DataKi:  560nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099914BDBM50099914(4-[4-(2,4-Dimethoxy-phenyl)-thiazol-2-yl]-5-methyl...)
Affinity DataKi:  640nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099933BDBM50099933(5-Methylsulfanyl-4-(4-thiophen-2-yl-thiazol-2-yl)-...)
Affinity DataKi:  700nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099907BDBM50099907(5-Methylsulfanyl-4-(4-o-tolyl-thiazol-2-yl)-thioph...)
Affinity DataKi:  850nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099898BDBM50099898(4-[4-(2-Methoxy-phenyl)-thiazol-2-yl]-5-methylsulf...)
Affinity DataKi:  850nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099918BDBM50099918(4-[4-(4-Chloro-3-nitro-phenyl)-thiazol-2-yl]-5-met...)
Affinity DataKi:  860nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099917BDBM50099917(4-[4-(4-Chloro-pyridin-3-yl)-thiazol-2-yl]-5-methy...)
Affinity DataKi:  870nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099904BDBM50099904(4-[4-(4-Methoxy-phenyl)-thiazol-2-yl]-5-methylsulf...)
Affinity DataKi:  900nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099924BDBM50099924(5-Methylsulfanyl-4-(4-m-tolyl-thiazol-2-yl)-thioph...)
Affinity DataKi:  960nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099929BDBM50099929(5-Methylsulfanyl-4-[4-(4-nitro-phenyl)-thiazol-2-y...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099920BDBM50099920(4-[4-(2-Chloro-pyridin-3-yl)-thiazol-2-yl]-5-methy...)
Affinity DataKi:  1.02E+3nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099909BDBM50099909(4-(4-Benzyl-thiazol-2-yl)-5-methylsulfanyl-thiophe...)
Affinity DataKi:  1.06E+3nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50147055BDBM50147055(4-{4-[5-(3-Methyl-butoxy)-1-phenyl-1H-pyrazol-4-yl...)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50109378BDBM50109378(5-Ethyl-4-(4-phenyl-thiazol-2-yl)-thiophene-2-carb...)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099916BDBM50099916(4-[4-(2,4-Dichloro-phenyl)-thiazol-2-yl]-5-methyls...)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50147053BDBM50147053(5-Methylsulfanyl-4-(5-phenyl-thiazol-2-yl)-thiophe...)
Affinity DataKi:  3.25E+3nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099925BDBM50099925(4-(4-Cyclohexyl-thiazol-2-yl)-5-methylsulfanyl-thi...)
Affinity DataKi:  4.70E+3nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Rat)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50147046BDBM50147046(5-Methylsulfanyl-4-[4-(5-propoxy-1-pyridin-2-yl-1H...)
Affinity DataKi:  5.00E+3nMAssay Description:In vitro binding affinity towards plasmin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50147046BDBM50147046(5-Methylsulfanyl-4-[4-(5-propoxy-1-pyridin-2-yl-1H...)
Affinity DataKi:  5.00E+3nMAssay Description:In vitro binding affinity towards Coagulation factor X was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50109381BDBM50109381(5-Methyl-4-(4-phenyl-thiazol-2-yl)-thiophene-2-car...)
Affinity DataKi:  6.00E+3nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50147057BDBM50147057(4-(4-Phenyl-thiazol-2-yl)-5-trifluoromethyl-thioph...)
Affinity DataKi:  1.25E+4nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50109379BDBM50109379(5-Methoxy-4-(4-phenyl-thiazol-2-yl)-thiophene-2-ca...)
Affinity DataKi:  1.44E+4nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099899BDBM50099899(4-(4-Biphenyl-4-yl-thiazol-2-yl)-5-methylsulfanyl-...)
Affinity DataKi:  1.54E+4nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50147049BDBM50147049(5-Ethylsulfanyl-4-(4-phenyl-thiazol-2-yl)-thiophen...)
Affinity DataKi: >2.00E+4nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50147052BDBM50147052(5-Benzylsulfanyl-4-(4-phenyl-thiazol-2-yl)-thiophe...)
Affinity DataKi: >2.00E+4nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50109374BDBM50109374(4-(4-Phenyl-thiazol-2-yl)-thiophene-2-carboxamidin...)
Affinity DataKi: >2.00E+4nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50147048BDBM50147048(5-Methanesulfonyl-4-(4-phenyl-thiazol-2-yl)-thioph...)
Affinity DataKi: >2.80E+4nMAssay Description:Inhibitory activity against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50147046BDBM50147046(5-Methylsulfanyl-4-[4-(5-propoxy-1-pyridin-2-yl-1H...)
Affinity DataKi: >5.00E+4nMAssay Description:In vitro binding affinity towards thrombin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed