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Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 50016536
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170205((R)-Phenyl-{[4-(4-pyridin-4-yl-phenyl)-thiophene-2...)
Affinity DataIC50:  14nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170206(4-(4'-Acetyl-biphenyl-4-yl)-thiophene-2-carboxylic...)
Affinity DataIC50:  57nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170203((4-Biphenyl-4-yl-thiophene-2-carbonyl)-carbamic ac...)
Affinity DataIC50:  70nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170207(CHEMBL180762 | [4-(2'-Hydroxy-biphenyl-4-yl)-thiop...)
Affinity DataIC50:  70nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170201(4-(4-Pyridin-4-yl-phenyl)-thiophene-2-carboxylic a...)
Affinity DataIC50:  100nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170201(4-(4-Pyridin-4-yl-phenyl)-thiophene-2-carboxylic a...)
Affinity DataIC50:  100nMAssay Description:Inhibition of Matrix metalloprotease-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170211((R)-Phenyl-{[4-(4-trifluoromethoxy-phenyl)-thiophe...)
Affinity DataIC50:  180nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50:  230nMAssay Description:Inhibition of Matrix metalloproteinase-12 in pressence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170205((R)-Phenyl-{[4-(4-pyridin-4-yl-phenyl)-thiophene-2...)
Affinity DataIC50:  270nMAssay Description:Inhibition of Matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170212(CHEMBL181817 | [4-(4-Trifluoromethoxy-phenyl)-thio...)
Affinity DataIC50:  400nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170209(4-Biphenyl-4-yl-thiophene-2-carboxylic acid (2-mor...)
Affinity DataIC50:  400nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170210(CHEMBL367148 | [4-(4-Trifluoromethoxy-phenyl)-thio...)
Affinity DataIC50:  400nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170208(4-(4-Cyclohexyl-phenyl)-thiophene-2-carboxylic aci...)
Affinity DataIC50:  460nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170203((4-Biphenyl-4-yl-thiophene-2-carbonyl)-carbamic ac...)
Affinity DataIC50: >1.20E+3nMAssay Description:Inhibition of Matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170211((R)-Phenyl-{[4-(4-trifluoromethoxy-phenyl)-thiophe...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of Matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170207(CHEMBL180762 | [4-(2'-Hydroxy-biphenyl-4-yl)-thiop...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of Matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170204((S)-Phenyl-{[4-(4-trifluoromethoxy-phenyl)-thiophe...)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of Matrix metalloprotease-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of Matrix metalloproteinase-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of Matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of Matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50: >1.01E+5nMAssay Description:Inhibition of Matrix metalloprotease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetStromelysin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50: >1.01E+5nMAssay Description:Inhibition of Matrix metalloprotease-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMatrix metalloproteinase-9(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50: >1.01E+5nMAssay Description:Inhibition of Matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed