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Report error Found 32 Enz. Inhib. hit(s) with all data for entry = 50037647
TargetMetabotropic glutamate receptor 4(Rat)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50007548((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Affinity DataKi:  160nMAssay Description:Displacement of [3H]L-AP4 from rat mGluR4 expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 8(Rat)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50007548((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Affinity DataKi:  1.90E+3nMAssay Description:Displacement of [3H]LY341495 from rat mGluR8 expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetMetabotropic glutamate receptor 4(Rat)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM17657((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Affinity DataKi:  3.40E+3nMAssay Description:Displacement of [3H]L-AP4 from rat mGluR4 expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 8(Rat)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM17657((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Affinity DataKi:  3.40E+3nMAssay Description:Displacement of [3H]LY341495 from rat mGluR8 expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 4(Rat)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50175072((S)-2-amino-2-((1R,2S)-2-phosphonocyclopropyl)acet...)
Affinity DataKi:  7.40E+3nMAssay Description:Displacement of [3H]L-AP4 from rat mGluR4 expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 4(Rat)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50175073((S)-2-amino-2-((1S,2R)-2-phosphonocyclopropyl)acet...)
Affinity DataKi:  5.30E+4nMAssay Description:Displacement of [3H]L-AP4 from rat mGluR4 expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 8(Rat)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50175073((S)-2-amino-2-((1S,2R)-2-phosphonocyclopropyl)acet...)
Affinity DataKi:  5.40E+4nMAssay Description:Displacement of [3H]LY341495 from rat mGluR8 expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 8(Rat)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50175072((S)-2-amino-2-((1R,2S)-2-phosphonocyclopropyl)acet...)
Affinity DataKi:  6.30E+4nMAssay Description:Displacement of [3H]LY341495 from rat mGluR8 expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50007548((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at human mGluR2 from BHK cells in [35S]GTP-gamma-S stimulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 7(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50007548((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Affinity DataEC50:  1.88E+5nMAssay Description:Activity at human mGluR7 by measuring cAMP formation in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 7(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50175073((S)-2-amino-2-((1S,2R)-2-phosphonocyclopropyl)acet...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at human mGluR7 by measuring cAMP formation in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Rat)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50007548((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at rat mGluR5 by measuring intracellular calcium concentration in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 1(Rat)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50175072((S)-2-amino-2-((1R,2S)-2-phosphonocyclopropyl)acet...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at rat mGluR1 by measuring intracellular calcium concentration in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Rat)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM17657((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Affinity DataEC50:  1.20E+3nMAssay Description:Activity at rat mGluR5 by measuring intracellular calcium concentration in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50175073((S)-2-amino-2-((1S,2R)-2-phosphonocyclopropyl)acet...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at human mGluR2 from BHK cells in [35S]GTP-gamma-S stimulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 4(Rat)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50175072((S)-2-amino-2-((1R,2S)-2-phosphonocyclopropyl)acet...)
Affinity DataEC50:  9.40E+3nMAssay Description:Functional activity at rat mGluR4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 7(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM17657((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at human mGluR7 by measuring cAMP formation in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 6(Rat)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50175073((S)-2-amino-2-((1S,2R)-2-phosphonocyclopropyl)acet...)
Affinity DataEC50:  4.60E+4nMAssay Description:Activity at rat mGluR6 by measuring cAMP formation in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 1(Rat)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM17657((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Affinity DataEC50:  7.30E+3nMAssay Description:Activity at rat mGluR1 by measuring intracellular calcium concentration in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 6(Rat)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM17657((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Affinity DataEC50:  7.60E+3nMAssay Description:Activity at rat mGluR6 by measuring cAMP formation in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Rat)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50175072((S)-2-amino-2-((1R,2S)-2-phosphonocyclopropyl)acet...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at rat mGluR5 by measuring intracellular calcium concentration in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 6(Rat)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50175072((S)-2-amino-2-((1R,2S)-2-phosphonocyclopropyl)acet...)
Affinity DataEC50:  1.30E+4nMAssay Description:Activity at rat mGluR6 by measuring cAMP formation in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 7(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50175072((S)-2-amino-2-((1R,2S)-2-phosphonocyclopropyl)acet...)
Affinity DataEC50:  7.00E+5nMAssay Description:Activity at human mGluR7 by measuring cAMP formation in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 4(Rat)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50175073((S)-2-amino-2-((1S,2R)-2-phosphonocyclopropyl)acet...)
Affinity DataEC50:  4.90E+4nMAssay Description:Functional activity at rat mGluR4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 1(Rat)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50007548((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at rat mGluR1 by measuring intracellular calcium concentration in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 1(Rat)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50175073((S)-2-amino-2-((1S,2R)-2-phosphonocyclopropyl)acet...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at rat mGluR1 by measuring intracellular calcium concentration in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 6(Rat)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50007548((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Affinity DataEC50:  340nMAssay Description:Activity at rat mGluR6 by measuring cAMP formation in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50175072((S)-2-amino-2-((1R,2S)-2-phosphonocyclopropyl)acet...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at human mGluR2 from BHK cells in [35S]GTP-gamma-S stimulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 5(Rat)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50175073((S)-2-amino-2-((1S,2R)-2-phosphonocyclopropyl)acet...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at rat mGluR5 by measuring intracellular calcium concentration in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 4(Rat)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM17657((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Affinity DataEC50:  6.10E+3nMAssay Description:Functional activity at rat mGluR4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM17657((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Affinity DataEC50:  2.60E+4nMAssay Description:Activity at human mGluR2 from BHK cells in [35S]GTP-gamma-S stimulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 4(Rat)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50007548((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Affinity DataEC50:  510nMAssay Description:Functional activity at rat mGluR4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed