Compile Data Set for Download or QSAR
Report error Found 28 Enz. Inhib. hit(s) with all data for entry = 50017366
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181073BDBM50181073(2-(3-chloro-benzyloxy)-6-methyl-isonicotinonitrile...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181066BDBM50181066(2-(3-(3-chlorobenzyloxy)-5-methylphenyl)isoindolin...)
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181075BDBM50181075(2-(3-chlorobenzyloxy)-6-chloroisonicotinonitrile |...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181076BDBM50181076(3-((3-(1,3-dioxoisoindolin-2-yl)-5-methylphenoxy)m...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181073BDBM50181073(2-(3-chloro-benzyloxy)-6-methyl-isonicotinonitrile...)
Affinity DataIC50: 9nMAssay Description:Inhibition of mGlu5 receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181067BDBM50181067(2-chloro-6-((2-methylpyridin-4-yl)methoxy)isonicot...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181079BDBM50181079(N-(2-(3-chlorobenzyloxy)-6-methylpyridin-4-yl)-N-m...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181065BDBM50181065(2-chloro-6-((2-chloropyridin-4-yl)methoxy)isonicot...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181077BDBM50181077(N-(2-(3-chlorobenzyloxy)-6-methylpyridin-4-yl)-2,2...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181084BDBM50181084(2-(3-chlorobenzyloxy)-N,6-dimethyl-N-(pyridin-3-yl...)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181070BDBM50181070(1-(3-(3-chlorobenzyloxy)-5-methylphenyl)-2-methyl-...)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181083BDBM50181083((5-(2-(3-chlorobenzyloxy)-6-methylpyridin-4-yl)oxa...)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181078BDBM50181078(pentyl 3-(3-chlorobenzyloxy)-5-methylphenyl(methyl...)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181081BDBM50181081(1-(2-(3-chlorobenzyloxy)-6-methylpyridin-4-yl)-2-m...)
Affinity DataKi:  44nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181069BDBM50181069(2-(3-chlorobenzyloxy)-4-(2,5-dimethyl-1H-pyrrol-1-...)
Affinity DataKi:  45nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181087BDBM50181087(N-(3-(3-chlorobenzyloxy)-5-methylphenyl)-2-(2,6-di...)
Affinity DataKi:  48nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181080BDBM50181080(2-(3-(benzyloxy)-5-methylphenyl)isoindoline-1,3-di...)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181068BDBM50181068(3-(3-(3-chlorobenzyloxy)-5-methylphenyl)pyridine |...)
Affinity DataKi:  58nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181062BDBM50181062(N-(3-(3-chlorobenzyloxy)-5-methylphenyl)-2-methoxy...)
Affinity DataKi:  70nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181065BDBM50181065(2-chloro-6-((2-chloropyridin-4-yl)methoxy)isonicot...)
Affinity DataIC50: 72nMAssay Description:Inhibition of mGlu5 receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181064BDBM50181064(1-(3-(3-chlorobenzyloxy)-5-methylphenyl)-2,5-dimet...)
Affinity DataKi:  160nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181086BDBM50181086(2-(3-(4-fluorobenzyloxy)-5-methylphenyl)isoindolin...)
Affinity DataKi:  900nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181074BDBM50181074(2-(3-(4-methoxybenzyloxy)-5-methylphenyl)isoindoli...)
Affinity DataKi:  1.50E+3nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181082BDBM50181082(2-(3-(benzyloxy)phenyl)isoindoline-1,3-dione | CHE...)
Affinity DataKi:  2.10E+3nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181072BDBM50181072(2-(3-chlorobenzyloxy)-6-(2,5-dimethyl-1H-pyrrol-1-...)
Affinity DataKi: >3.00E+3nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181063BDBM50181063(4-(3-chlorobenzyloxy)-2-(2,5-dimethyl-1H-pyrrol-1-...)
Affinity DataKi: >3.00E+3nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181085BDBM50181085(2-(3-(4-chlorobenzyloxy)-5-methylphenyl)isoindolin...)
Affinity DataKi:  3.90E+3nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50181071BDBM50181071(2-[3-methyl-5-(4-methyl-benzyloxy)-phenyl]-isoindo...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]MPEP from recombinant human mGlu5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed