Compile Data Set for Download or QSAR
maximum 50k data
Found 40 Enz. Inhib. hit(s) with all data for entry = 50017913
TargetMu-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188374(1-phenyl-8-(2-phenyl-cyclohexyl)-1,3,8-triaza-spir...)
Affinity DataIC50:  150nMAssay Description:Displacement of [3H]naloxone from human mu opioid receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188803((S)-4-phenyl-8-((1R,2R)-2-phenyl-cyclohexyl)-2,8-d...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of hERG potassium channel expressed in CHO cells by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188364(8-[2-(4-fluoro-phenyl)-2-hydroxy-cyclohexyl]-4-phe...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of hERG potassium channel expressed in CHO cells by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188376(8-(2-hydroxy-2-phenyl-cyclohexyl)-1-phenyl-1,3,8-t...)
Affinity DataIC50:  2.70E+3nMAssay Description:Displacement of [3H]naloxone from human mu opioid receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188803((S)-4-phenyl-8-((1R,2R)-2-phenyl-cyclohexyl)-2,8-d...)
Affinity DataIC50:  3.92E+3nMAssay Description:Displacement of [3H]naloxone from human mu opioid receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188374(1-phenyl-8-(2-phenyl-cyclohexyl)-1,3,8-triaza-spir...)
Affinity DataIC50:  6.00E+3nMAssay Description:Displacement of [3H]NOP from human NOP receptors expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188803((S)-4-phenyl-8-((1R,2R)-2-phenyl-cyclohexyl)-2,8-d...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]NOP from human NOP receptors expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188364(8-[2-(4-fluoro-phenyl)-2-hydroxy-cyclohexyl]-4-phe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]NOP from human NOP receptors expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188364(8-[2-(4-fluoro-phenyl)-2-hydroxy-cyclohexyl]-4-phe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]NOP from human NOP receptors expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188376(8-(2-hydroxy-2-phenyl-cyclohexyl)-1-phenyl-1,3,8-t...)
Affinity DataIC50:  1.50E+4nMAssay Description:Displacement of [3H]NOP from human NOP receptors expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188364(8-[2-(4-fluoro-phenyl)-2-hydroxy-cyclohexyl]-4-phe...)
Affinity DataIC50:  2.40E+4nMAssay Description:Displacement of [3H]naloxone from human mu opioid receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188364(8-[2-(4-fluoro-phenyl)-2-hydroxy-cyclohexyl]-4-phe...)
Affinity DataIC50:  2.40E+4nMAssay Description:Displacement of [3H]naloxone from human mu opioid receptor expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188368(4-(4-fluoro-phenyl)-8-(2-hydroxy-2-phenyl-cyclohex...)
Affinity DataIC50: >2.40E+7nMAssay Description:Inhibition of hERG potassium channel expressed in CHO cells by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188358(4-(4-fluoro-phenyl)-8-[2-(2-fluoro-phenyl)-2-hydro...)
Affinity DataEC50:  596nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188360(4-(4-fluoro-phenyl)-8-[2-(3-fluoro-phenyl)-2-hydro...)
Affinity DataEC50:  95nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188359(4-(4-fluoro-phenyl)-8-(2-hydroxy-2-p-tolyl-cyclohe...)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188803((S)-4-phenyl-8-((1R,2R)-2-phenyl-cyclohexyl)-2,8-d...)
Affinity DataEC50:  232nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188376(8-(2-hydroxy-2-phenyl-cyclohexyl)-1-phenyl-1,3,8-t...)
Affinity DataEC50:  44nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188366(8-[2-(3-chloro-phenyl)-2-hydroxy-cyclohexyl]-4-(4-...)
Affinity DataEC50:  118nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188371(4-(4-fluoro-phenyl)-8-[2-hydroxy-2-(3-methoxy-phen...)
Affinity DataEC50:  158nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188374(1-phenyl-8-(2-phenyl-cyclohexyl)-1,3,8-triaza-spir...)
Affinity DataEC50:  26nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188379(4-(4-fluorophenyl)-8-[2-(3-fluorophenyl)-2-hydroxy...)
Affinity DataEC50:  474nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188372(4-(4-fluoro-phenyl)-8-(2-hydroxy-2-m-tolyl-cyclohe...)
Affinity DataEC50:  2.64E+3nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188380(8-[2-hydroxy-2-(4-methoxy-phenyl)-cyclohexyl]-4-ph...)
Affinity DataEC50:  4.48E+3nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188370(4-(4-fluoro-phenyl)-8-[2-hydroxy-2-(4-trifluoromet...)
Affinity DataEC50:  1.31E+3nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188803((S)-4-phenyl-8-((1R,2R)-2-phenyl-cyclohexyl)-2,8-d...)
Affinity DataEC50:  2.50E+4nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188377(4-(4-fluoro-phenyl)-8-[2-hydroxy-2-(4-methanesulfo...)
Affinity DataEC50:  1.86E+4nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188364(8-[2-(4-fluoro-phenyl)-2-hydroxy-cyclohexyl]-4-phe...)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188364(8-[2-(4-fluoro-phenyl)-2-hydroxy-cyclohexyl]-4-phe...)
Affinity DataEC50:  70nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188362(4-(4-fluoro-phenyl)-8-[2-hydroxy-2-(4-methoxy-phen...)
Affinity DataEC50:  1.12E+3nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188378(4-(4-fluoro-phenyl)-8-[2-hydroxy-2-(2-trifluoromet...)
Affinity DataEC50:  1.39E+3nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188369(4-{2-[4-(4-fluoro-phenyl)-1-oxo-2,8-diaza-spiro[4....)
Affinity DataEC50:  1.95E+3nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188363(8-[2-(4-fluoro-phenyl)-2-hydroxy-cyclohexyl]-1-phe...)
Affinity DataEC50:  24nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188375(4-(4-fluoro-phenyl)-8-(2-hydroxy-2-o-tolyl-cyclohe...)
Affinity DataEC50:  596nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188376(8-(2-hydroxy-2-phenyl-cyclohexyl)-1-phenyl-1,3,8-t...)
Affinity DataEC50:  7.20E+4nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188373(8-[2-hydroxy-2-(3-methoxy-phenyl)-cyclohexyl]-4-ph...)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188374(1-phenyl-8-(2-phenyl-cyclohexyl)-1,3,8-triaza-spir...)
Affinity DataEC50:  1.20E+4nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT2 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188365(8-[2-(3-fluoro-phenyl)-2-hydroxy-cyclohexyl]-4-phe...)
Affinity DataEC50:  158nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188367(8-[2-(4-tert-butyl-phenyl)-2-hydroxy-cyclohexyl]-4...)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50188803((S)-4-phenyl-8-((1R,2R)-2-phenyl-cyclohexyl)-2,8-d...)
Affinity DataEC50:  232nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT1 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed