Compile Data Set for Download or QSAR
Report error Found 72 Enz. Inhib. hit(s) with all data for entry = 50018190
LigandChemical structure of BindingDB Monomer ID 50192528BDBM50192528(1-(2-(4-fluoro-3-methylphenoxy)-5-((2-(pyrrolidin-...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of [125I]MCH binding to human MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192536BDBM50192536(1-(2-(3,4-difluorophenoxy)-5-((2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of [125I]MCH binding to human MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192518BDBM50192518(1-(2-(3,4-dimethylphenoxy)-5-((2-(pyrrolidin-1-yl)...)
Affinity DataKi:  2nMAssay Description:Inhibition of [125I]MCH binding to rat MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192534BDBM50192534(1-(5-((2-(pyrrolidin-1-yl)ethyl)carbamoyl)-2-(p-to...)
Affinity DataIC50: 2nMAssay Description:Inhibition of [125I]MCH binding to human MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192535BDBM50192535(1-(5-((2-(pyrrolidin-1-yl)ethyl)carbamoyl)-2-(m-to...)
Affinity DataIC50: 2nMAssay Description:Inhibition of [125I]MCH binding to human MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192521BDBM50192521(1-(2-(3,4-dimethylphenoxy)-5-((2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 2nMAssay Description:Inhibition of [125I]MCH binding to human MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192518BDBM50192518(1-(2-(3,4-dimethylphenoxy)-5-((2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 3nMAssay Description:Inhibition of [125I]MCH binding to rat MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192521BDBM50192521(1-(2-(3,4-dimethylphenoxy)-5-((2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 3nMAssay Description:Inhibition of [125I]MCH binding to rat MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192518BDBM50192518(1-(2-(3,4-dimethylphenoxy)-5-((2-(pyrrolidin-1-yl)...)
Affinity DataKi:  3.30nMAssay Description:Inhibition of [125I]MCH binding to mouse MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192518BDBM50192518(1-(2-(3,4-dimethylphenoxy)-5-((2-(pyrrolidin-1-yl)...)
Affinity DataKi:  4.70nMAssay Description:Inhibition of [125I]MCH binding to human MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192518BDBM50192518(1-(2-(3,4-dimethylphenoxy)-5-((2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 5nMAssay Description:Inhibition of [125I]MCH binding to mouse MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192522BDBM50192522(1-(4-bromophenyl)-3-(2-(3,4-dimethylphenoxy)-5-((2...)
Affinity DataIC50: 5nMAssay Description:Inhibition of [125I]MCH binding to rat MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192528BDBM50192528(1-(2-(4-fluoro-3-methylphenoxy)-5-((2-(pyrrolidin-...)
Affinity DataIC50: 6nMAssay Description:Inhibition of [125I]MCH binding to rat MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192531BDBM50192531(1-(2-chlorophenyl)-3-(2-(3,4-dimethylphenoxy)-5-((...)
Affinity DataIC50: 7nMAssay Description:Inhibition of [125I]MCH binding to mouse MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192518BDBM50192518(1-(2-(3,4-dimethylphenoxy)-5-((2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 7nMAssay Description:Inhibition of [125I]MCH binding to human MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192535BDBM50192535(1-(5-((2-(pyrrolidin-1-yl)ethyl)carbamoyl)-2-(m-to...)
Affinity DataIC50: 7nMAssay Description:Inhibition of [125I]MCH binding to rat MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192516BDBM50192516(1-(2-(3-fluorophenoxy)-5-((2-(pyrrolidin-1-yl)ethy...)
Affinity DataIC50: 9nMAssay Description:Inhibition of [125I]MCH binding to human MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192518BDBM50192518(1-(2-(3,4-dimethylphenoxy)-5-((2-(pyrrolidin-1-yl)...)
Affinity DataKd:  10nMAssay Description:Antagonist activity at MCHR1 by Schild experimentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192522BDBM50192522(1-(4-bromophenyl)-3-(2-(3,4-dimethylphenoxy)-5-((2...)
Affinity DataIC50: 11nMAssay Description:Inhibition of [125I]MCH binding to human MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192518BDBM50192518(1-(2-(3,4-dimethylphenoxy)-5-((2-(pyrrolidin-1-yl)...)
Affinity DataKi:  13nMAssay Description:Activity at rat MCHR1 expressed in CHOK1-Gqi cells assessed as inhibition of MCH-induced calcium ion release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192518BDBM50192518(1-(2-(3,4-dimethylphenoxy)-5-((2-(pyrrolidin-1-yl)...)
Affinity DataKi:  13nMAssay Description:Activity at human MCHR1 expressed in CHOK1-Gqi cells assessed as inhibition of MCH-induced calcium ion release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192518BDBM50192518(1-(2-(3,4-dimethylphenoxy)-5-((2-(pyrrolidin-1-yl)...)
Affinity DataKi:  14nMAssay Description:Activity at mouse MCHR1 expressed in CHOK1-Gqi cells assessed as inhibition of MCH-induced calcium ion release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192531BDBM50192531(1-(2-chlorophenyl)-3-(2-(3,4-dimethylphenoxy)-5-((...)
Affinity DataIC50: 14nMAssay Description:Inhibition of [125I]MCH binding to rat MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192531BDBM50192531(1-(2-chlorophenyl)-3-(2-(3,4-dimethylphenoxy)-5-((...)
Affinity DataIC50: 15nMAssay Description:Inhibition of [125I]MCH binding to human MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192522BDBM50192522(1-(4-bromophenyl)-3-(2-(3,4-dimethylphenoxy)-5-((2...)
Affinity DataIC50: 28nMAssay Description:Inhibition of [125I]MCH binding to mouse MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192536BDBM50192536(1-(2-(3,4-difluorophenoxy)-5-((2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 28nMAssay Description:Inhibition of [125I]MCH binding to rat MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192534BDBM50192534(1-(5-((2-(pyrrolidin-1-yl)ethyl)carbamoyl)-2-(p-to...)
Affinity DataIC50: 33nMAssay Description:Inhibition of [125I]MCH binding to rat MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192516BDBM50192516(1-(2-(3-fluorophenoxy)-5-((2-(pyrrolidin-1-yl)ethy...)
Affinity DataIC50: 40nMAssay Description:Inhibition of [125I]MCH binding to rat MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192526BDBM50192526(3-(3-biphenyl-4-yl-ureido)-4-(3,4-dimethyl-phenoxy...)
Affinity DataIC50: 140nMAssay Description:Inhibition of [125I]MCH binding to human MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192530BDBM50192530(4-(3,4-dimethylphenoxy)-3-((1R,2R)-2-phenylcyclopr...)
Affinity DataIC50: 170nMAssay Description:Inhibition of [125I]MCH binding to human MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192527BDBM50192527(3-cinnamamido-4-(3,4-dimethylphenoxy)-N-(2-(pyrrol...)
Affinity DataIC50: 170nMAssay Description:Inhibition of [125I]MCH binding to rat MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192527BDBM50192527(3-cinnamamido-4-(3,4-dimethylphenoxy)-N-(2-(pyrrol...)
Affinity DataIC50: 230nMAssay Description:Inhibition of [125I]MCH binding to mouse MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192532BDBM50192532(4-(3,4-dimethylphenoxy)-3-(3-phenylpropanamido)-N-...)
Affinity DataIC50: 250nMAssay Description:Inhibition of [125I]MCH binding to rat MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192526BDBM50192526(3-(3-biphenyl-4-yl-ureido)-4-(3,4-dimethyl-phenoxy...)
Affinity DataIC50: 260nMAssay Description:Inhibition of [125I]MCH binding to rat MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192530BDBM50192530(4-(3,4-dimethylphenoxy)-3-((1R,2R)-2-phenylcyclopr...)
Affinity DataIC50: 320nMAssay Description:Inhibition of [125I]MCH binding to rat MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192532BDBM50192532(4-(3,4-dimethylphenoxy)-3-(3-phenylpropanamido)-N-...)
Affinity DataIC50: 330nMAssay Description:Inhibition of [125I]MCH binding to human MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192533BDBM50192533(1-(2-(3,4-dimethylphenoxy)-5-((2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 340nMAssay Description:Inhibition of [125I]MCH binding to human MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192520BDBM50192520(4-(naphthalen-2-yloxy)-3-(3-phenylpropanamido)-N-(...)
Affinity DataIC50: 340nMAssay Description:Inhibition of [125I]MCH binding to mouse MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192520BDBM50192520(4-(naphthalen-2-yloxy)-3-(3-phenylpropanamido)-N-(...)
Affinity DataIC50: 380nMAssay Description:Inhibition of [125I]MCH binding to human MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192526BDBM50192526(3-(3-biphenyl-4-yl-ureido)-4-(3,4-dimethyl-phenoxy...)
Affinity DataIC50: 400nMAssay Description:Inhibition of [125I]MCH binding to mouse MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192533BDBM50192533(1-(2-(3,4-dimethylphenoxy)-5-((2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 460nMAssay Description:Inhibition of [125I]MCH binding to mouse MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192527BDBM50192527(3-cinnamamido-4-(3,4-dimethylphenoxy)-N-(2-(pyrrol...)
Affinity DataIC50: 540nMAssay Description:Inhibition of [125I]MCH binding to human MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192520BDBM50192520(4-(naphthalen-2-yloxy)-3-(3-phenylpropanamido)-N-(...)
Affinity DataIC50: 540nMAssay Description:Inhibition of [125I]MCH binding to rat MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192532BDBM50192532(4-(3,4-dimethylphenoxy)-3-(3-phenylpropanamido)-N-...)
Affinity DataIC50: 610nMAssay Description:Inhibition of [125I]MCH binding to mouse MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192533BDBM50192533(1-(2-(3,4-dimethylphenoxy)-5-((2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 610nMAssay Description:Inhibition of [125I]MCH binding to rat MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192515BDBM50192515(phenyl 2-(3,4-dimethylphenoxy)-5-((2-(pyrrolidin-1...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of [125I]MCH binding to mouse MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192525BDBM50192525(3-acetamido-4-(3,4-dimethylphenoxy)-N-(2-(pyrrolid...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of [125I]MCH binding to human MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192524BDBM50192524(4-(3,4-dimethylphenoxy)-3-(2-phenylacetamido)-N-(2...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of [125I]MCH binding to human MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192514BDBM50192514(4-(3,4-dimethylphenylamino)-3-(3-phenylpropanamido...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of [125I]MCH binding to human MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50192525BDBM50192525(3-acetamido-4-(3,4-dimethylphenoxy)-N-(2-(pyrrolid...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of [125I]MCH binding to rat MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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