Compile Data Set for Download or QSAR
maximum 50k data
Found 16 Enz. Inhib. hit(s) with all data for entry = 50018619
TargetNeprilysin(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197517((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of rat NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197517((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of rabbit NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197517((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...)
Affinity DataIC50:  2.30nMpH: 7.0Assay Description:Inhibition of human kidney NEP at pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197513((S)-2-((1-((2-(hydroxymethyl)-2,3-dihydro-1H-inden...)
Affinity DataIC50:  3.70nMpH: 7.0Assay Description:Inhibition of human kidney NEP at pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197519((S)-2-{1-[3-(4-fluoro-phenyl)-propylcarbamoyl]-cyc...)
Affinity DataIC50:  4.60nMpH: 7.0Assay Description:Inhibition of human kidney NEP at pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197517((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of human recombinant NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197507((S)-4-methoxy-2-{1-[(1R,2S)-2-(4-methoxy-phenyl)-c...)
Affinity DataIC50:  6.10nMpH: 7.0Assay Description:Inhibition of human kidney NEP at pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197513((S)-2-((1-((2-(hydroxymethyl)-2,3-dihydro-1H-inden...)
Affinity DataIC50:  10nMpH: 7.4Assay Description:Inhibition of human kidney NEP at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190746((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)
Affinity DataIC50:  10.2nMAssay Description:Inhibition of rabbit NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197517((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...)
Affinity DataIC50:  10.5nMpH: 7.4Assay Description:Inhibition of human kidney NEP at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197519((S)-2-{1-[3-(4-fluoro-phenyl)-propylcarbamoyl]-cyc...)
Affinity DataIC50:  12.6nMpH: 7.4Assay Description:Inhibition of human kidney NEP at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197507((S)-4-methoxy-2-{1-[(1R,2S)-2-(4-methoxy-phenyl)-c...)
Affinity DataIC50:  13.8nMpH: 7.4Assay Description:Inhibition of human kidney NEP at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190746((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)
Affinity DataIC50:  14.3nMAssay Description:Inhibition of rat NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190746((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)
Affinity DataIC50:  18.9nMpH: 7.0Assay Description:Inhibition of human kidney NEP at pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190746((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)
Affinity DataIC50:  19.7nMAssay Description:Inhibition of human recombinant NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190746((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)
Affinity DataIC50:  31.8nMpH: 7.4Assay Description:Inhibition of human kidney NEP at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed